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001-es BibID:	BIBFORM071091
035-os BibID:	(WoS)000415723800016 (Scopus)85034075239
Első szerző:	Tsivgoulis, Georgios
Cím:	Intravenous thrombolysis for patients with in-hospital stroke onset : propensity-matched analysis from the Safe Implementation of Treatments in Stroke-East registry / Georgios Tsivgoulis, Aristeidis H. Katsanos, Pavla Kadlecová, Anna Czlonkowska, Adam Kobayashi, Miroslav Brozman, Viktor Švigelj, Laszlo Csiba, Klara Fekete, Janika Kõrv, Vida Demarin, Aleksandras Vilionskis, Dalius Jatuzis, Yakup Krespi, Theodore Karapanayiotides, Sotirios Giannopoulos, Robert Mikulik
Dátum:	2017
ISSN:	1351-5101
Megjegyzések:	Introduction: Recent cross-sectional study data suggest that intravenous thrombolysis (IVT) in patients with in-hospital (IHS) acute ischemic stroke (AIS) onset is associated with unfavourable functional outcomes at hospital discharge and in-hospital mortality compared to patients with outof-hospital stroke onset (OHS) treated with IVT. We sought to compare outcomes between IVT treated IHS and OHS patients by analysing propensity score matched (PSM) data from the SITSEAST registry. Methods: We compared the following outcomes for all PSM patients: 1.symptomatic intracranial hemorrhage (sICH) defined with the SITS-MOST criteria, 2.favourable functional outcome Accepted ArticleThis article is protected by copyright. All rights reserved. (FFO) defined as a modified Rankin Scale (mRS) score of 0-1 at three months, 3.Functional independence (FI) defined as a mRS score of 0-2 at three months, 4.3-month mortality. Results: Out of total 19,077 IVT-treated AIS patients, 196 IHS patients were matched to 5124 OHS patients, with no differences in all baseline characteristics (p>0.1). IHS had longer door-to-needle [90 min (60-140) vs. 65 (47-95), p<0.001] and door-to-imaging times [40 min (20-90) vs 24 (15-35), p<0.001] compared to OHS. No differences were detected in the rates of sICH (1.6% vs 1.9%, p=0.756), FFO (46.4% vs 42.3%, p=0.257), FI (60.7% vs. 60.0%,p=0.447) and mortality (14.3% vs 15.1%,p=0.764). The distribution of 3-month mRS-scores was similar in the two groups (p=0.273). Conclusions: Our findings underline the safety and efficacy of IVT for IHS. They also underscore the potential of reducing in-hospital delays for timely tPA delivery in patients with IHS.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk intravenous thrombolysis acute ischemic stroke in-hospital stroke onset-to-treatment time door-to-needle time stroke awareness
Megjelenés:	European Journal of Neurology. - 24 : 12 (2017), p. 1493-1498. -
További szerzők:	Katsanos, Aristeidis H. Kadlecova, Pavla Czlonkowska, Anna Kobayashi, Adam Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Kõrv, Janika Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Karapanayiotides, Theodore Giannopoulos, Sotirios Mikulík, Robert
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