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001-es BibID:	BIBFORM071096
Első szerző:	van der Kraan, Peter
Cím:	Age-Related Alterations in Signaling Pathways in Articular Chondrocytes : implications for the Pathogenesis and Progression of Osteoarthritis - A Mini-Review / van der Kraan Peter, Matta Csaba, Mobasheri Ali
Dátum:	2017
ISSN:	0304-324X
Megjegyzések:	Musculoskeletal conditions are a major burden on individuals, healthcare systems, and social care systems throughout the world, with indirect costs having a predominant economic impact. Aging is a major contributing factor to the development and progression of arthritic and musculoskeletal diseases. Indeed, aging and inflammation (often referred to as ♭inflammaging') are critical risk factors for the development of osteoarthritis (OA), which is one of the most common forms of joint disease. The term ♭chondrosenescence' has recently been introduced to define the age-dependent deterioration of chondrocyte function and how it undermines cartilage function in OA. An important component of chondrosenescence is the age-related deregulation of subcellular signaling pathways in chondrocytes. This mini-review discusses the role of age-related alterations in chondrocyte signaling pathways. We focus our attention on two major areas: age-dependent alterations in transforming growth factor-? signaling and changes in protein kinase and phosphoprotein phosphatase activities in aging chondrocytes. A better understanding of the basic signaling mechanisms underlying aging in chondrocytes is likely to facilitate the development of new therapeutic and preventive strategies for OA and a range of other age-related osteoarticular disorders.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Gerontology 63 : 1 (2017), p. 29-35. -
További szerzők:	Matta Csaba (1980-) (molekuláris biológus, genetikus, angol szakfordító) Mobasheri, Ali
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