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001-es BibID:BIBFORM071242
Első szerző:Pataki Emese (molekuláris biológus)
Cím:fhl1 controls transcription of the nitrogen starvation induced genes in cooperation with TORC1 in Schizosaccharomyces pombe / Emese Pataki, Ronit Weisman, Mátyás Sipiczki, Ida Miklós
Dátum:2015
ISSN:1217-8950 1588-2640
Megjegyzések:One of the most important regulators of cellular processes is the protein kinase TOR (Target ofRapamycin), which is conserved from yeast to humans. TOR is a protein kinase that was isolated asthe target of the immunosuppressive and anticancer drug rapamycin. It regulates the response toenvironmental changes and cellular energy status, cell growth, cell proliferation, cell survival,protein synthesis, and transcription. In the fission yeast, Schizosaccharomyces pombe there are twoTOR homologs. Tor1 is part of a protein complex known as TORC2, while Tor2 is part of a proteincomplex known as TORC1. These complexes were found to regulate oppositely the response tonutrient depletion, in particular the response to nitrogen starvation. TORC1 is essential and playsmajor role in the control of cellular growth, while TORC2 regulates cell survival under stressconditions. Here we demonstrate that overexpression of fhl1+ gene suppresses the mRNA level ofthe nitrogen starvation response genes: mei2, ste4, ste11 and decreases the mating efficiency of tor2-ts mutant. Moreover overexpression of fhl1+ modifies the stress response of tor2-ts mutant, amongothers in the presence of rapamycin.Based on these findings we can conclude that fhl1 plays a role in the TOR pathway and tor2controls the response to nitrogen starvation via fhl1 transcription factor.
Tárgyszavak:Természettudományok Biológiai tudományok idézhető absztrakt
Megjelenés:Acta Microbiologica et Immunologica Hungarica 62 : Suppl. (2015), p. 197-197. -
További szerzők:Weisman, Ronit Sipiczki Mátyás (1948-) (biológus) Miklós Ida (1962-) (biológus)
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