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001-es BibID:	BIBFORM071303
Első szerző:	Stiedl, P.
Cím:	A possible dependency model of single nucleotide polymorphisms in the development of periodontitis in the Hungarian population / P. Stiedl, C. Paska, G. Jobbagy-Ovari, G. Hullam, B. Burghardt, B. Soos, I. Tar, I. Marton, G. Nagy, P. Hermann, G. Nagy, C. Szalai, P. Antal, G. Varga, I. I. Gera
Dátum:	2015
ISSN:	0303-6979
Megjegyzések:	Aim: Genetic variabilities e.g. single nucleotide polymorphisms(SNP) are hot spot area on investigating the background ofmultifactorial diseases. Confused data exist about the role ofSNPs in the development of periodontitis in several countries,however a complex analysis is missing up to now. We aimed tosee not only the prevalence of 17 SNPs of 12 genes in the Hungarianpopulation, but also to generate a potential dependencymodel with a novel complex statistical approach.Material and Methods: We collected oral mucosal scrapingsfrom 432 volunteers categorized into gingivitis (Gin, N = 97),aggressive (AP, N = 65) and chronic (CP, N = 166) periodontitis,and control (Con, N = 104) groups. Genotyping was madeby RT-PCR. Over the conventional frequentist statisticalapproach, Bayesian network based multilevel analysis of relevance(BN-BMLA) was also applied.Results: Except for TNFa-1031 all the investigated SNPs werein Hardy-Weinberg Equilibrium. From several per se significantSNPs only the IL1b+3954, ANRIL (AP-Con) and IL-6-1363(Gin-Con) remained relevant after corrections for multiplehypothesis testing and were also confirmed by logistic regression.With the BN-BMLA method we created a possibledependency model in which ANRIL, IL1b+3954, IL-6-1363,CD14-260 take part as covariates.Conclusion: We investigated the possibility to create a complexmodel containing the dependency relationships between AP, CPand gingivitis and their relevant factors. As results we detectedsome unique interactions, which were not detected with conventionalstatistical methods previously. These findings supplementedwith additional studies may provide firm basis for thedevelopment of new diagnostic strategies and provide novel toolsfor early detection and primary control of periodontitis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt gene polimorphisms periodontitis SNP
Megjelenés:	Journal Of Clinical Periodontology 42 (2015), p. 154. -
További szerzők:	Páska Csilla Jobbágy-Óvári G. Hullám G. Burghardt, B. Soós Boglárka (1988-) (általános orvos) Tar Ildikó (1967-) (fogszakorvos) Márton Ildikó (1954-) (fogszakorvos) Nagy Gábor (fogorvos, Semmelweis) Hermann Péter Nagy G. (Pécs) Szalai Csaba Antal Péter Varga G. Gera I. I.
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