Találati lista | Tudóstér

001-es BibID:	BIBFORM071387
Első szerző:	Harangi Mariann (belgyógyász, endokrinológus)
Cím:	HDL subfraction distribution and HDL function in untreated dyslipidemic patients / Harangi Mariann, Szentpéteri Anita, Nádró Bíborka, Lőrincz Hajnalka, Seres Ildikó, Páll Dénes, Paragh György
Dátum:	2017
ISSN:	2574-1209
Megjegyzések:	Aim: The protective role of high-density lipoprotein (HDL) against atherosclerosis is wellknown. However, both structural and functional changes of the HDL particles may affect itsprotective efficacy. Increased levels of HDL-associated myeloperoxidase (MPO) and decreasedHDL-linked paraoxonase-1 (PON1) activity have been reported in dyslipidemic patients. Somechanges in HDL subfraction distributions were also studied previously, but data on structuraland functional changes in dyslipidemia are not complete. Therefore, the authors aimed toevaluate these qualitative and quantitative markers of HDL in dyslipidemic patients andhealthy control subjects. Methods: Anthropometric parameters, serum levels of lipoproteinsand MPO, as well as PON1 activities were investigated in 81 untreated dyslipidemic patientsand in 32 healthy gender-matched controls. Additionally, HDL subfractions were detectedby an electrophoretic method on polyacrylamide gel (Lipoprint). Results: Significantlyhigher glucose, hemoglobin A1c, total cholesterol, low-density lipoprotein-cholesterol,triglyceride, lipoprotein(a), apolipoprotein B, C-reactive protein, and MPO levels were foundin patients compared to the healthy subjects. There were no significant differences in PON1paraoxonase and arylesterase activities between the two study groups, but MPO/PON1 ratiowas significantly higher in patients. There was a shift towards the smaller HDL subfractions,but only the intermediate HDL ratio was significantly lower in patients compared to controls.Conclusion: The results highlight the importance of HDL-associated pro- and antioxidantenzymes suggesting the possible clinical benefit of MPO/PON1 calculation and confirm thatquantification of HDL-C level alone provides limited data regarding HDL's cardioprotectiveeffect. Calculation of MPO/PON1 ratio may be a useful cardiovascular marker in dyslipidemia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban subfraction paraoxonase myeloperoxidase dyslipidemia high-density lipoprotein
Megjelenés:	Vessel Plus. - 1 (2017), p. 166-173. -
További szerzők:	Szentpéteri Anita (1988-) (biológus) Nádró Bíborka (1992-) (általános orvos) Lőrincz Hajnalka (1986-) (biológus) Seres Ildikó (1954-) (biokémikus) Páll Dénes (1967-) (belgyógyász, kardiológus) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00062 GINOP OTKA-115723 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: