Találati lista | Tudóstér

001-es BibID:	BIBFORM071996
035-os BibID:	(WoS)000428997200007 (Scopus)85042164621
Első szerző:	Csősz Éva (biokémikus, molekuláris biológus)
Cím:	Salivary proteome profiling of oral squamous cell carcinoma in a Hungarian population / Éva Csősz, Bernadett Márkus, Zsuzsanna Darula, Katalin F. Medzihradszky, Judit Nemes, Emese Szabó, József Tőzsér, Csongor Kiss, Ildikó Márton
Dátum:	2018
ISSN:	2211-5463
Megjegyzések:	Oral squamous cell carcinoma (OSCC) is the 7th most common malignancy and the 9th most frequent site of cancer death in Europe. Hungary occupies top places of statistics regarding OSCC incidence and mortality. Therefore, there is a high need to improve early detection. Saliva, as a readily available body fluid, became an increasingly important substance for the detection of biomarkers. Different research groups identified salivary biomarkers specific for different countries. In this study saliva samples of Hungarian OSCC patients were studiedin order to discover disease- and perhaps region-specific biomarkers. LC/MS/MS analysis on linear ion trap-Orbitrap mass spectrometer was used for qualitative and quantitative salivary protein profiling. More than 500 proteins were identified from saliva by shotgun proteomics. The up- and downregulated proteins in the saliva of patients with OSCC highlighted the importance of protein-protein interaction networks involving the immune system and proteolysis in disease development. Two potential biomarkers from our shotgun analysis and a third candidate reported earlier by a Taiwanese group were further examined by ELISA on a larger reference set of samples. Resistin reported as a biomarker in Taiwan but not validated in our study highlights the necessity of application of standardized analysis methods in different ethnic or geographical populations in order to identify biomarkers with sufficient specificity and sensitivity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk OSCC biomarker proteomic analysis ELISA
Megjelenés:	FEBS Open Bio. - 8 : 4 (2018), p. 556-569. -
További szerzők:	Márkus Bernadett (1989-) (molekuláris biológus) Darula Zsuzsanna Medzihradszky-Fölkl Katalin Nemes Judit (1968-) (fogszakorvos) Szabó Emese (1992-) (biotechnológus) Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész) Kiss Csongor (1956-) (hematológus, onkológus) Márton Ildikó (1954-) (fogszakorvos)
Pályázati támogatás:	OTKA-105034 OTKA TÁMOP-4.2.2.D-15/1/KONV-2015-0016 TÁMOP GINOP-2.3.2-15-2016-00020 Egyéb GINOP-2.3.2-15-2016-00001 Egyéb
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI Szerző által megadott URL
Borító:
Saját polcon: