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001-es BibID:	BIBFORM072268
Első szerző:	Kardos Zsófia
Cím:	Increased frequency of temporal acoustic window failure in rheumatoid arthritis : a manifestation of altered bone metabolism? / Kardos Zsófia, Oláh Csaba, Sepsi Mariann, Sas Attila, Kostyál László, Bóta Tünde, Bhattoa Harjit Pal, Hodosi Katalin, Kerekes György, Tamási László, Bereczki Dániel, Szekanecz Zoltán
Dátum:	2018
ISSN:	0770-3198
Megjegyzések:	Assessment of intracranial vessels includes transcranial Doppler (TCD). TCD performance requires intact temporal acousticwindows (TAW). Failure of TAW (TAWF) is present in 8?20% of people. There have been no reports on TAWF in rheumatoidarthritis (RA). Altogether, 62 female RA patients were included. Among them, 20 were MTX-treated and biologic-free, 20received infliximab, and 22 tocilizumab. The controls included 60 non-RA women. TAWF, temporal bone thickness, and texturewere determined by ultrasound and CT. BMD and T-scores of multiple bones were determined by DEXA. Several bonebiomarkers were assessed by ELISA. In RA, 54.8% of the patients had TAWF on at least one side. Neither TAW could beidentified in 34% of RA subjects. In contrast, only 20.0% of control subjects had TAWF on either or both sides (p < 0.001). In RAvs controls, 53.0 vs 2.9% of subjects exerted the trilayer, Bsandwich-like^ structure of TAW (p < 0.001). Finally, in RA vscontrols, the mean temporal bone thickness values of the right TAW were 3.58 ? 1.43 vs 2.92 ? 1.22 mm (p = NS), while thoseof the left TAW were 4.16 ? 1.56 vs 2.90 ? 1.16 mm (p = 0.001). There was close association between TAWF, bone thickness,and texture (p < 0.05). These TAW parameters all correlated with age; however, TAW failure and texture also correlated withserum osteoprotegerin. TAW bone thickness inversely correlated with hip BMD (p < 0.05). TAWF, thicker, and heterogeneoustemporal bones were associated with RA. These features have been associated with bone loss and OPG production. Bone lossseen in RA may result in OPG release and stimulation of bone formation around TAW.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Biological therapy BMD Osteoporosis Osteoprotegerin Reumatoid arthritis Temporal acoustic window failure
Megjelenés:	Clinical Rheumatology. - 37 : 5 (2018), p. 1183-1188. -
További szerzők:	Oláh Csaba (1972-) (idegsebész) Sepsi Marianna Sas Attila Kostyál László (1974-) (radiológus) Bóta Tünde Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Hódosi Katalin Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Tamási László Bereczki Dániel (1960-) (neurológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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