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001-es BibID:	BIBFORM072946
Első szerző:	Bencze János (orvos)
Cím:	Biological function of Lemur tyrosine kinase 2 (LMTK2) : implications in neurodegeneration / János Bencze, Gábor Miklós Mórotz, Woosung Seo, Viktor Bencs, János Kálmán, Christopher Charles John Miller, Tibor Hortobágyi
Dátum:	2018
ISSN:	1756-6606
Megjegyzések:	Neurodegenerative disorders are frequent, incurable diseases characterised by abnormal protein accumulationand progressive neuronal loss. Despite their growing prevalence, the underlying pathomechanism remainsunclear. Lemur tyrosine kinase 2 (LMTK2) is a member of a transmembrane serine/threonine-protein kinase family.Although it was described more than a decade ago, our knowledge on LMTK2's biological functions is still insufficient.Recent evidence has suggested that LMTK2 is implicated in neurodegeneration. After reviewing the literature, weidentified three LMTK2-mediated mechanisms which may contribute to neurodegenerative processes: disrupted axonaltransport, tau hyperphosphorylation and enhanced apoptosis. Moreover, LMTK2 gene expression is decreased in anAlzheimer's disease mouse model. According to these features, LMTK2 might be a promising therapeutic target in nearfuture. However, further investigations are required to clarify the exact biological functions of this unique protein.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Alzheimer's disease Axonal transport LMTK2 Neurodegeneration Tau
Megjelenés:	Molecular Brain. - 11 : 20 (2018), p. 1-9. -
További szerzők:	Mórotz Miklós Gábor Woosung Seo Bencs Viktor (1995-) (orvos) Kálmán János Miller, Christopher Charles John Hortobágyi Tibor (1965-) (patológus)
Pályázati támogatás:	ÚNKP-17-3 ÚNKP EFOP-3.6.3-VEKOP-16-2017-00009 EFOP GINOP-2.3.2-15-2016-00043 GINOP 2017- 1.2.1-NKP-2017-00002 Egyéb
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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