Találati lista | Tudóstér

001-es BibID:	BIBFORM073362
Első szerző:	Fehérvári Imre
Cím:	Mitigation of cytokine storm by intraoperative use of renal replacement therapy during combined liver-kidney transplantation / I. Fehervari, J. Fazakas, Z. Gerlei, B. Nemes, L. Kobori
Dátum:	2010
ISSN:	0041-1345
Megjegyzések:	Combined liver-kidney transplantation (CLKT) is a widely used multiorgan transplantation with good graft survival rates. Previous studies have shown beneficial effects of renal replacement therapy in critically ill patients. This observation led us to use intraoperative continuous veno-venous hemofiltration (CVVH) during multiorgan transplantations. METHODS: We analyzed (CRP) inflammatory response parameters of tumor necrosis factor (TNF)alpha, interleukin(IL)-6, procalcitonin (PCT) and C-reactive protein (CRP) at various stages of the combined transplantations. RESULTS: All patients survived with well-functioning grafts. Mean +/- SD follow-up was 32.8 +/- 14.2 months. During the whole operation we used intraoperative CVVH starting at the beginning and continuing in the intensive care unit (ICU) afterward (mean +/- SD, 11.2 +/- 8.4 hours). Intraoperative TNFalpha, IL-6, CRP, and PCT were measured before surgery, during hepatectomy in the anhepatic phase, before and after liver reperfusion, exactly before kidney reperfusion, after kidney reperfusion, and upon arrival in the ICU. The wash-out of cytokines together with hemodynamic stability gave optimal circumstances for recovery of the transplanted organs. CONCLUSIONS: CVVH-based therapy offered stable intraoperative parameters, prevention of fluid overload, correction of metabolic disturbances, and wash-out of cytokines, which gave optimal circumstances for recovery of transplanted organs.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Transplantation Proceedings 42 : 6 (2010), p. 2353-2356. -
További szerzők:	Fazakas János Gerlei Zsuzsa Nemes Balázs Áron (1969-) (sebész) Kóbori László
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: