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001-es BibID:	BIBFORM073620
Első szerző:	Galimberti, Sara
Cím:	Vascular Endothelial Growth Factor Polymorphisms in Mantle Cell Lymphoma / Galimberti S., Nagy B., Palumbo G. A., Ciancia E., Buda G., Orciuolo E., Melosi A., Lambelet P., Ronca F., Petrini M.
Dátum:	2010
ISSN:	0001-5792
Megjegyzések:	In this study, we determined the allele and genotype frequencies of vascular endothelial growth factor (VEGF) G+405C, C-460T, C+936T and C-2578A single nucleotide polymorphisms (SNPs) in 32 patients affected by mantle cell lymphoma (MCL) and 58 healthy controls. Real-time PCR combined with melting curve analysis was used for the determination of SNP alleles. A significant difference in the allele frequency of VEGFC-460T and C+936T SNPs in MCL and healthy cases was not observed. On the contrary, VEGF G+405C and C-2578A SNP allele distribution was significantly lower in the patient group than among normal controls (p = 0.014, p = 0.001). This observation suggests that further investigation is warranted, both in vitro and in a larger series of patients, to further examine the role of VEGF polymorphisms in the pathogenesis of MCL. In addition, the use of quantitative real-time PCR combined with a melting curve analysis method in the detection of the 4 VEGF SNPs may have the potential to replace older and more time-consuming PCR-RFLP methods and bears further investigation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban VEGF Mantle cell lymphoma
Megjelenés:	Acta Haematologica 123 : 2 (2010), p. 91-95. -
További szerzők:	Nagy Bálint (1956-) (molekuláris genetikus) Palumbo, Giuseppe Alberto Ciancia, Eugenio Buda, G. Orciuolo, E. Melosi, A. Lambelet, P. Ronca, F. Petrini, Mario
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