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001-es BibID:	BIBFORM074285
Első szerző:	Szilágyi Melinda (biológus)
Cím:	MiR200a, miR200b and miR200c are promising candidate biomarkers in epithelial ovarian cancer / Melinda Szilágyi-Bónizs, Éva Márton, János Lukács, Beáta Soltész, Eszter Janka, András Penyige, Róbert Póka, Bálint Nagy
Dátum:	2018
Megjegyzések:	Ovarian cancer is the fifth most common form of cancer death among women. Developing a fast, reliable blood test would facilitate the early detection of ovarian cancer, which would also contribute to the improvement of survival chances. Screening circulating miRNAs proved to be reliable biomarkers in various cancers. MiRNAs are also dysregulated in ovarian cancer, however, only a few publications focus on their diagnostic role. We screened 6 miRNAs in the plasma samples of healthy (n=30), previously untreated epithelial ovarian carcinoma patients (n=21, FIGO stages III or IV) and patients with benign masses (n=14). The relative amount of miRNAs was detected by qRT-PCR.The expression levels of miR200a, miR200b and miR200c were elevated in the malignant samples compared to the healthy donors (p<0.001). The level of miR200a was also higher in malignant than benign samples (p<0.01). However, no significant difference was detected in the expression of miR205, miR483 and let7f. ROC-AUC was the highest in the case of miR200a (0.875, 95%CI=0.76-0.99) and it was still promising in the case of miR200b (0.85, 95%CI=0.72-0.98) and miR200c (0.83, 95%CI=0.70-0.97). Spearman's rank correlation was relatively high between the expression values of miR200b and miR200c (rs = 0.858; p<0.001) and these miRNAs shared several target genes involved in cancer development according to target prediction analysis. The agreement of diagnostic tests based on miR200s and CA125 or HE4 proved to be weak according to Cohen's kappa values.We conclude that miR200a, miR200b and miR200c might be promising complementary markers of CA125 and HE4 in ovarian cancer. Moreover miR200a is also a reliable biomarker in the differential diagnosis of benign tumors.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt ovarian cancer cell-free mtDNA miRNA
Megjelenés:	Biomedical Papers. - 162 : Suppl. 1 (2018), p. S11. -
További szerzők:	Márton Éva (1992-) (biológus) Lukács János (1975-) (szülész-nőgyógyász, genetikus) Soltész Beáta (1987-) (molekuláris biológus) Janka Eszter Anna (1989-) (bőrgyógyász, népegészségügyi szakember) Penyige András (1954-) (molekuláris genetikus) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Nagy Bálint (1956-) (molekuláris genetikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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