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001-es BibID:	BIBFORM074287
Első szerző:	Soltész Beáta (molekuláris biológus)
Cím:	Cell-free miRNAs as potential biomarkers in the diagnosis of ovarian cancer / Beáta Soltész, Orsolya Biró, János Lukács, András Penyige, Róbert Póka, Bálint Nagy
Dátum:	2018
Megjegyzések:	cause of cancer mortality among women due to the poor early diagnostic tools for the detection of this type of aggressive tumour. Cell-free microRNAs appear to be potential candidate biomarker in this early diagnosis.Materials and methods: Eleven ovarian cancer patients and 11 healthy controls were involved into the study. EDTA-anticoagulated blood was drawn; the microRNA was isolated with miRNeasy Mini kit (Qiagen, Germany) and cDNA was synthesised. The miR-103; miR-125, miR-193b and miR-200b expression were determined by miRCURY Universal RT microRNA PCR Starter kit (Exiqon, USA). The results were normalised to the miRNA-93 reference gene. Student t-test was used for the statistical calculations.Results: Significant difference in the expression of miR-103 (p=0.001), miR-193b (p=0.0236), miR-125 (p=0.029) and miR-200b (p=0.0273) was detected among the cancer patients and controls.Conclusion: The expression of four different cell-free microRNAs was determined from the plasma of patients with ovarian cancer and healthy controls. Significant difference was found in the expression of the analysed microRNAs. In the near future, our study will be extended on higher number of cases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt ovarian cancer mirNA cell-free
Megjelenés:	Biomedical Papers. - 162 : Suppl. 1 (2018), p. S13. -
További szerzők:	Biró Orsolya (molekuláris biológus) Lukács János (1975-) (szülész-nőgyógyász, genetikus) Penyige András (1954-) (molekuláris genetikus) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Nagy Bálint (1956-) (molekuláris genetikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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