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001-es BibID:	BIBFORM074846
Első szerző:	Heikinheimo, Kristiina
Cím:	Genetic changes in sporadic keratocystic odontogenic tumors (odontogenic keratocysts) / K. Heikinheimo, K. J. Jee, P. R. Morgan, B. Nagy, S. Knuutila, I. Leivo
Dátum:	2007
ISSN:	0022-0345
Megjegyzések:	Little is known about the genetic background of keratocystic odontogenic tumors (KCOT, odontogenic keratocysts). Our aim was to characterize genomic aberrations in sporadic KCOT using cDNA-expression arrays and array-comparative genomic hybridization. For cDNA-expression arrays, 10 KCOT specimens and 20 fetal tooth germs were studied. Quantitative real-time reverse-transcription/polymerase chain-reaction and immunohistochemical studies were also undertaken. Several genes were over-expressed in 12q13, including cytokeratin 6B (KRT6B) ( approximately 10-fold), epidermal growth factor receptor ERBB3 (approximately 4.7-fold), and glioma-associated oncogene homologue 1 (GLI1) (approximately 5- to 12-fold). One amplicon (approximately 0.7 Mega base pairs [Mbp]), covering several genes involved in the regulation of cell growth, was found in 12q13.2. Deletions were found in 3q13.1, 5p14.3, and 7q31.3, including the cell-adhesion-related gene cadherin 18 (CDH18) and leukocyte cell adhesion molecule (ALCAM, MEMD). Over-expressed and amplified genes in 12q13, also reported in several other tumors and cell lines, may contribute to the persistent growth characteristics of KCOT.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban odontogenic tumor genetic changes
Megjelenés:	Journal of Dental Research. - 86 : 6 (2007), p. 544-549. -
További szerzők:	Jee, Kowan Ja Morgan, Peter R. Nagy Bálint (1956-) (molekuláris genetikus) Knuutila, Sakari Leivo, Ilmo
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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