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001-es BibID:	BIBFORM075286
035-os BibID:	(cikkazonosító)818
Első szerző:	Zsuga Judit (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Cím:	Blind spot for sedentarism : redefining the diseasome of physical inactivity in view of circadian system and the irisin/BDNF axis / Judit Zsuga, Csaba E. More, Tamas Erdei, Csaba Papp, Szilvia Harsanyi, Rudolf Gesztelyi
Dátum:	2018
ISSN:	1664-2295
Megjegyzések:	Introduction: The term "diseasome of physical inactivity" was coined by Pedersen to explain clustering of chronic diseases linked to physical inactivity. Accordingly, physical inactivity per se contributes to the accumulation of visceral fat, which, generates chronic low-grade systemic inflammation, contributes to emergence of chronic, non-communicable diseases. Diversity of these disorders posits the possible involvement of a supraphysiological system. Methods: Hypothesis driven literature search and deductive reasoning was used to review relevant literature and formulate a novel theory. Results: We have identified the circadian system, omnipresent in virtually every cell, as a possible vehicle for brain muscle crosstalk, explaining some aspects of the diseasome of physical inactivity This system is hierarchically organized, with the suprachiasmatic nucleus (SCN) being the master clock that entrains to the dark/light cycle and synchronizes subsidiary molecular clocks in the periphery. Insufficient photic entrainment also causes chronic disease evolution. The recently identified irisin, was shown to induce brain-derived neurotrophic factor (BDNF) production in several brain areas. BDNF assumes significant role in gating light's influence in the retinohypothalamic synapse, by having a permissive effect on glutamate signal transduction underlying photic entrainment. Conclusions: Here we provide theoretical evidence to support the hypothesis that irisin may facilitate photic entrainment of the SCN, via BDNF. By this irisin opens up possible pathways for peripheral non-photic entrainment signals to exert influence on the master clock that is otherwise resistant to these. Furthermore, we suggest that intertwining processes of circadian, redox, inflammatory and myokine systems lay underneath the diseasome of physical inactivity.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban cirkadián ritmus circadian rhythm irisin BDNF
Megjelenés:	Frontiers in Neurology. - 9 (2018), p. 1-13. -
További szerzők:	Móré Elek Csaba (1966-) (pszichiáter szakorvos) Erdei Tamás Dániel (1992-) (kísérletes farmakológus) Papp Csaba (1966-) (aneszteziológus és intenzív terápiás szakorvos) Kolozsváriné Harsányi Szilvia (1983-) (okleveles egészségpolitikai szakértő) Gesztelyi Rudolf (1969-) (kísérletes farmakológus)
Pályázati támogatás:	EFOP-3.6.2-16-2017-00009 EFOP Establishing Thematic Scientific and Cooperation Network for Clinical Research GINOP-2.3.2-15-2016-00005 GINOP 2017-1.2.1-NKP-2017-00002 egyéb
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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