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001-es BibID:	BIBFORM075443
035-os BibID:	(cikkazonosító)1390 (WoS)000448821300056 (Scopus)85054091771
Első szerző:	Lucas, Renata
Cím:	Reduced Carotenoid and Retinoid Concentrations and Altered Lycopene Isomer Ratio in Plasma of Atopic Dermatitis Patients / Lucas Renata, Mihály Johanna, Lowe Gordon, Graham Daniel, Szklenar Monika, Szegedi Andrea, Töröcsik Daniel, Rühl Ralph
Dátum:	2018
ISSN:	2072-6643
Megjegyzések:	Abstract: Carotenoids and retinoids are known to alter the allergic response with important physiological roles in the skin and the immune system. In the human organism various carotenoids are present, some of which are retinoid precursors. The bioactive derivatives of these retinoids are the retinoic acids, which can potently activate nuclear hormone receptors such as the retinoic acid receptor and the retinoid X receptor. In this study, we aimed to assess how plasma carotenoid and retinoid concentrations along with the ratio of their isomers are altered in atopic dermatitis (AD) patients (n = 20) compared to healthy volunteers (HV, n = 20). The study indicated that plasma levels of the carotenoids lutein (HV 198 14 ng/mL, AD 158 12 ng/mL, p = 0.02; all values in mean SEM), zeaxanthin (HV 349 30 ng/mL, AD 236 18 ng/mL, p 0.01), as well as the retinoids retinol (HV 216 20 ng/mL, AD 167 17 ng/mL, p = 0.04) and all-trans-retinoic acid (HV 1.1 0.1 ng/mL, AD 0.7 0.1 ng/mL, p = 0.04) were significantly lower in the AD-patients, while lycopene isomers, -carotene, and -carotene levels were comparable to that determined in the healthy volunteers. In addition, the ratios of 13-cis- vs. all-trans-lycopene (HV 0.31 0.01, AD 0.45 0.07, p = 0.03) as well as 13-cis- vs. all-trans-retinoic acid (HV 1.4 0.2, AD 2.6 0.6, p = 0.03) were increased in the plasma of AD-patients indicating an AD-specific 13-cis-isomerisation. A positive correlation with SCORAD was calculated with 13-cis- vs. all-trans-lycopene ratio (r = 0.40, p = 0.01), while a negative correlation was observed with zeaxanthin plasma levels (r = ??0.42, p = 0.01). Based on our results, we conclude that in the plasma of AD-patients various carotenoids and retinoids are present at lower concentrations, while the ratio of selected lycopene isomers also differed in the AD-patient group. An increase in plasma isomers of both lycopene and retinoic acid may cause an altered activation of nuclear hormone receptor signaling pathways and thus may be partly responsible for the AD-phenotype.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk lycopene carotene retinoic acid retinoid vitamin A RAR RXR
Megjelenés:	Nutrients. - 10 : 10 (2018), p. 1-12. -
További szerzők:	Mihály Johanna (1982-) (biológus, vegyész) Lowe, Gordon Graham, Daniel Szklenár Mónika Szegedi Andrea (1964-) (bőrgyógyász) Töröcsik Dániel (1979-) (bőrgyógyász) Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP K109362 OTKA K 128250 NKFIH
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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