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001-es BibID:	BIBFORM075687
Első szerző:	Kozma Bence (szülész-nőgyógyász)
Cím:	The Effects of Heat Exposure on Vaginal Smooth Muscle Cells : elastin and Collagen Production / Bence Kozma, Keith Candiotti, Róbert Póka, Péter Takács
Dátum:	2018
ISSN:	0378-7346
Megjegyzések:	Aims: To evaluate smooth muscle cells (SMCs) proliferation and elastin and collagen production after heat exposure (65 ? C). Methods: Samples were taken from the anterior vaginal wall, SMCs were cultured, and heated to 65 ? C for 30 and 60 s. Cell proliferation was assessed; tropoelastin and collagen production was measured. Results: Heat does not affect SMC proliferation at 65 ? C neither at 30 nor at 60 s. Surfacedeposited elastin level was significantly increased after heat exposure (mean ? SD, 30 s 155 ? 5% of control [p < 0.01] and 60 s 516 ? 40% of control [p < 0.01]). Tropoelastin levels in the culture media were significantly lower after 60 s of heat exposure (mean ? SD, 30 s 102 ? 5% of control [p = ns] and 60 s 70 ? 2% of control [p = 0.04]). Significant increase in surface-deposited collagen production was found (mean ? SD, 30 s 170 ? 6% of control [p < 0.01] and 60 s 123 ? 6% of control [p < 0.01]), but no such elevation was measured in the media after heat exposure (mean ? SD, 30 s 120 ? 20% of control [p = ns] and 60 s 100 ? 20% of control [p = ns]). Conclusion: When SMCs are exposed to heat there is significant elevation in collagen and elastin production. Changes in the composition of the extracellular matrix after heat exposure may contribute to vaginal wall remodeling.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Gynecologic And Obstetric Investigation. - 83 : 3 (2018), p. 247-251. -
További szerzők:	Candiotti, Keith Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Takács Péter (1968-) (szülész-nőgyógyász)
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