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001-es BibID:	BIBFORM076218
035-os BibID:	(cikkazonosító)1776 (WoS)000463100200001 (Scopus)85068267109
Első szerző:	Szakács Zsolt
Cím:	Aging and Comorbidities in Acute Pancreatitis II. : a Cohort-analysis of 1203 Prospectively Collected Cases / Zsolt Szakács, Noémi Gede, Dániel Pécsi, Ferenc Izbéki, Mária Papp, György Kovács, Eszter Fehér, Dalma Dobszai, Balázs Kui, Katalin Márta, Klára Kónya, Imre Szabó, Imola Török, László Gajdán, Tamás Takács, Patrícia Sarlós, Szilárd Gódi, Márta Varga, József Hamvas, Áron Vincze, Andrea Szentesi, Andrea Párniczky, Peter Hegyi
Dátum:	2019
Megjegyzések:	Introduction: Our meta-analysis indicated that aging influences the outcomes of acute pancreatitis (AP), however, a potential role for comorbidities was implicated, as well. Here we aimed to determine how age and comorbidities modify the outcomes in AP in a cohort-analysis of Hungarian AP cases. Materials and methods: Data of patients diagnosed with AP by the revised Atlanta criteria were extracted from the Hungarian National Pancreas Registry. Outcomes of interest were mortality, severity, length of hospitalization, local, and systemic complications of AP. Comorbidities were measured by means of Charlson Comorbidity Index (CCI) covering pre-existing chronic conditions. Non-parametric univariate and multivariate statistics were used in statistical analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Results: A total of 1203 patients from 18 centers were included. Median age at admission was 58 y (range: 18-95 y), median CCI was 2 (range: 0-10). Only severe comorbidities (CCI?3) predicted mortality (OR=4.48; CI: 1.57-12.80). Although severe comorbidities predicted AP severity (OR=2.10, CI: 1.08-4.09), middle (35-64 years) and old age (?65 years) were strong predictors with borderline significance, as well (OR=7.40, CI: 0.99-55.31 and OR=6.92, CI: 0.91-52.70, respectively). Similarly, middle and old age predicted a length of hospitalization ?9 days. Interestingly, the middle-aged (35-64 years) were three times more likely to develop pancreatic necrosis than young adults (OR=3.21, CI: 1.26-8.19), whereas the old-aged (?65 years) were almost nine times more likely to develop systemic complications than young adults (OR=8.93, CI: 1.20-66.80), though having severe comorbidities (CCI?3) was a predisposing factor, as well. Conclusion: Both aging and comorbidities modify the outcomes of AP. Comorbidities seem to be decisive regarding mortality and severity, however, age is a strong predictor of the latter, as well. The middle-aged are the most likely to develop local complications, whereas those having severe comorbidities are vulnerable to developing systemic complications. Studies validating the implementation of CCI-based predictive scores are awaited.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk acute pancreatitis comorbidities mortality severity length of hospitalization complications prediction Charlson Comorbidity Index
Megjelenés:	Frontiers in Physiology. - 2019 (2019). -
További szerzők:	Gede Noémi Pécsi Dániel Izbéki Ferenc Papp Mária (1975-) (belgyógyász, gasztroenterológus) Kovács György (1982-) (belgyógyász, gasztroenterológus) Fehér Krisztina Eszter (1991-) (orvos) Dobszai Dalma Kui Balázs Márta Katalin Kónya Klára Szabó Imre Török Imola Gajdán László Takács Tamás (Szeged) Sarlós Patrícia Gódi Szilárd Varga Márta Hamvas József Vincze Áron Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász)
Pályázati támogatás:	KH125678 OTKA K116634 OTKA K120335 OTKA GINOP-2.3.2-15-2016-00048 GINOP EFOP-3.6.2-16-2017-00006 EFOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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