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001-es BibID:	BIBFORM076941
035-os BibID:	(WOS)000475558500040 (Scopus)85060540723
Első szerző:	Molnár Csaba (pathológus)
Cím:	Thyroid Carcinoma Coexisting with Hashimoto's Thyreoiditis : clinicopathological and Molecular Characteristics Clue up Pathogenesis / Csaba Molnár, Sarolta Molnár, Judit Bedekovics, Attila Mokánszki, Ferenc Győry, Endre Nagy, Gábor Méhes
Dátum:	2019
ISSN:	1219-4956 1532-2807
Megjegyzések:	Thyroid cancer (TC) coexisting with Hashimoto's thyroiditis (HT) presents with several characteristic features including multifocality and lower clinical stages compared to de novo carcinomas but its exact biology is still not understood. We reexamined clinico-pathological and molecular correlations between Hashimoto's thyroditis and papillary thyroid cancer. A total of 262 patients with TC was evaluated who underwent thyroidectomy at the Surgical Department of the University of Debrecen. Clinical data, histology and molecular data were evaluated. Our cohort included 43 patients (16.4%) with (5 male, 38 female) and 219 (83.6%) patients without coexisting HT (48 male, 171 female). Hashimoto's thyroiditis related thyroid cancer presented predominantly (93.0% of the cases) with the papillary histological type. Multifocality was observed more frequently with coexisting HT (16/40; 40.0%) compared to cases uninvolved (45/190; 23.7%)(p?=?0.034). In contrast, lymphatic metastasis (pN1) with a significantly reduced frequency in patients with HT (4/11; 36.4%) then without HT (34/41 pN1; 82.9%)(p?=?0.002). BRAF V600E mutation could be demonstrated at significantly lower rates in cases of PTC?+?HT (32.1 vs 60.7%, p?<?0.005). High incidence, multifocality and papillary morphology strongly support a causal relation between TC and preexisting Hashimoto's thyroiditis, the latter to be considered as a preneoplastic condition promoting thyroid carcinogenesis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Carcinoma Clinicopathology Hashimoto thyreoiditis Molecular pathology Thyroid
Megjelenés:	Pathology & Oncology Research. - 25 : 3 (2019), p. 1191-1197. -
További szerzők:	Deliné Molnár Sarolta (1990-) (patológus) Bedekovics Judit (1986-) (orvos) Mokánszki Attila (1983-) (molekuláris biológus Ph.D hallgató) Győry Ferenc (1969-) (kardiológus) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Méhes Gábor (1966-) (patológus)
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