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001-es BibID:	BIBFORM077046
035-os BibID:	(WoS)000485146200010 (Scopus)85070584761
Első szerző:	Deutschmann, Claudia
Cím:	Identification of Chitinase-3-like protein 1 as a novel neutrophil antigenic target in Crohn's disease / Deutschmann Claudia, Sowa Mandy, Murugaiyan Jayaseelan, Roesler Uwe, Röber Nadja, Conrad Karsten, Laass Martin, Bogdanos Dimitrios, Sipeki Nora, Papp Maria, Rödiger Stefan, Roggenbuck Dirk, Schierack Peter
Dátum:	2019
ISSN:	1873-9946
Megjegyzések:	Background and Aims: There is an increasing incidence of inflammatory bowel disease [IBD]. Autoimmune responses are involved in the pathophysiology of IBD, but their underlying pathways and target antigens have not yet been fully elucidated. Methods: Autoantigenic targets in IBD were identified after separation of whole cell proteins isolated from neutrophils using two-dimensional electrophoresis and matrix assisted laser desorption ionization - time of flight mass spectrometry-based protein identification of the spots that displayed Western blotting signals with anti-neutrophil cytoplasmic antibody-positive sera. The prevalence of IgG, IgA and secretory IgA [sIgA] to chitinase 3-like protein 1 [CHI3L1] was analysed by enzyme-linked immunosorbent assays using recombinant CHI3L1 in 110 patients with Crohn's disease [CD], 95 with ulcerative colitis [UC], 126 with coeliac disease [CeD] and 86 healthy controls [HCs]. Results: The 18-glycosylhydrolase family member CHI3L1 was identified as a neutrophil autoantigenic target. CD patients displayed significantly higher levels of IgG to CHI3L1 than patients with UC and CeD (p < 0.0001, respectively). IgA and sIgA to CHI3L1 was significantly higher in CD than in UC, CeD and HCs [p < 0.0001, respectively]. IgA and sIgA to CHI3L1 demonstrated the highest prevalence in CD [25.5%, 28/110; and 41.8%%, 46/110] compared to HCs [2.3%, 2/86; and 4.7%%, 4/86; p < 0.0001, respectively] and are associated with a more complicated progression of CD. Conclusion: CHI3L1 is a novel neutrophil autoantigenic target in CD. IgA and sIgA to CHI3L1 may serve as novel markers for CD and may facilitate the serological diagnosis of IBD.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk inflammatory bowel disease chitinase-3 like protein 1 autoantibody Crohn's disease enzyme-linked immunosorbent assay
Megjelenés:	Journal of Crohns & Colitis. - 13 : 7 (2019), p. 894-904. -
További szerzők:	Sowa, Mandy Murugaiyan, Jayaseelan Roesler, Uwe Röber, Nadja Conrad, Karsten Laass, Martin Bogdanos, Dimitrios P. Sipeki Nóra (1987-) (általános orvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Rödiger, Stefan Roggenbuck, Dirk Schierack, Peter
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