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001-es BibID:	BIBFORM077074
Első szerző:	Bajor Judit
Cím:	HLA-DQ2 homozygosis increases tTGA levels at diagnosis but does not influence the clinical phenotype of celiac disease : a multicenter study / Bajor Judit, Szakacs Zsolt, Juhasz Mark, Papp Maria, Kocsis Dorottya, Szegedi Eva, Foldi Ildiko, Farkas Nelli, Hegyi Peter, Vincze Aron
Dátum:	2019
ISSN:	1744-3121 1744-313X
Megjegyzések:	Background and purpose: Magnitude of gluten-specific T-cell responses in celiac disease might be dependent on HLA-DQ2 gene dose. We aimed to investigate the effects of HLA-DQB102 allele dose on clinical outcomes. Methods: We reviewed the charts of all celiac patients attending to three Hungarian university clinics after 1997 and included those patients, who 1) were diagnosed with celiac disease, 2) underwent high resolution HLA-typing, and 3) were ?18 years at the time of data collection. HLA typing was performed to determine DQB102 allele dose. Patients were divided into risk groups by DQB102 allele dose, as follows: high-, intermediate-, and low-risk groups corresponded to a double, single, and zero doses, respectively. We used ANOVA and Person's chi-squared test to explore association between HLA-risk and clinical variables. Results: 727 celiac patients attended the clinics but only 105 (14.4%) patients were eligible for inclusion. High, intermediate, and low HLA-risk patients comprised 35.3%, 52.3%, and 12.3% of the study population, respectively. Double dose of HLADQB102 was more frequent in patient with high tTGA level (> 10 times the upper limit of normal) (p=0.045). Gene dose was not associated with younger age at diagnosis (p=0.549), gender (p=0.739), more severe diagnostic histology (p=0.318), more frequent classical presentation (p=0.846), anemia (p=0.611), metabolic bone disease (p=0.374), dermatitis herpetiformis (p=0.381), and autoimmune diseases (p=0.837). Conclusions: Our study shows a significant gene dose effect in terms of tTGA level at diagnosis, but no significant association between HLA-DQB1*02 allele dose and the clinical outcomes in celiac disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	International Journal of Immunogenetics. - 46 : 2 (2019), p. 74-81. -
További szerzők:	Szakács Zsolt Juhász Márk Félix Papp Mária (1975-) (belgyógyász, gasztroenterológus) Kocsis Dorottya Szegedi Éva Földi Ildikó (1981-) (orvos) Farkas Nelli Hegyi Péter Jenő (belgyógyász) Vincze Áron
Pályázati támogatás:	ÚNKP-17-3-II ÚNKP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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