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001-es BibID:	BIBFORM077181
035-os BibID:	(cikkazonosító)202 (WOS)000424904100001 (Scopus)85042080133
Első szerző:	Sváb Domonkos
Cím:	Identification and Characterization of T5-Like Bacteriophages Representing Two Novel Subgroups from Food Products / Sváb Domonkos, Falgenhauer Linda, Rohde Manfred, Szabó Judit, Chakraborty Trinad, Tóth István
Dátum:	2018
ISSN:	1664-302X
Megjegyzések:	During recent years, interest in the use of bacteriophages as biocontrol agents against foodborne pathogens has increased, particularly for members of the family Enterobacteriaceae, with pathogenic Escherichia coli, Shigella, and Salmonella strains among them. Here, we report the isolation and characterisation of 12 novel T5-like bacteriophages from confiscated food samples. All bacterophages effectively lysed E. coli K-12 strains and were able to infect pathogenic E. coli strains representing enterohaemorrhagic (EHEC), enteropathogenic (EPEC), enterotoxigenic (ETEC), and enteroinvasive (EIEC) pathotypes, Shigella dysenteriae, S. sonnei strains, as well as multidrug-resistant (MDR) E. coli and multiple strains representing different Salmonella enterica serovars. All the bacteriophages exhibited Siphoviridae morphology. Whole genome sequencing of the novel T5-like bacteriophages showed that they represent two distinct groups, with the genome-based grouping correlating to the different host spectra. As these bacteriophages are of food origin, their stability and lack of any virulence genes, as well as their broad and mutually complementary host spectrum makes these new T5-like bacteriophages valuable candidates for use as biocontrol agents against foodborne pathogenic enterobacteria.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk bacteriophages T5-like phages phage genomics Enterobacteriaceae food safety bio-control
Megjelenés:	Frontiers in Microbiology. - 9 (2018), p. 1-11. -
További szerzők:	Falgenhauer, Linda Rohde, Manfred Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Chakraborty, Trinad Tóth István (Budapest)
Pályázati támogatás:	124335 NKFIH
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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