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001-es BibID:	BIBFORM077455
Első szerző:	Mokánszki Attila (molekuláris biológus Ph.D hallgató)
Cím:	Altered microRNAs expression levels of sperm and seminal plasma in patients with infertile ejaculates compared with normozoospermic males / Mokánszki Attila, Molnár Zsuzsanna, Varga Tóthné Emese, Bodnár Béla, Jakab Attila, Bálint Bálint L., Balogh István
Dátum:	2020
ISSN:	1464-7273 1742-8149
Megjegyzések:	Approximately 15% of couples are unable to conceive after one year of unprotected intercourse. Because sperm can be accessed with ease, it is reasonable to search for non-invasive biomarkers in semen. MicroRNAs are a family of short single-stranded non-coding RNA molecules that are capable of regulating gene expression and causing mRNA degradation. We studied the most common 11 spermatogenesis-related microRNAs expression levels in sperm and seminal plasma from patients with oligozoospermic or asthenozoospermic ejaculates, and in men with normo- zoospermic ejaculates. Five of these miRNAs were significantly upregulated and three were downregulated in infertile males compared to men with normozoospermic ejaculates. A statistic- ally significant negative correlation was found between the sperm concentration and several microRNA expression level (let-7a, miR-7-1-3p, miR-141, miR-200a, and miR-429, p < 0.0001) both in sperm and in seminal plasma. We also found positive correlation between sperm concentra- tion and some miRNA expression levels (miR-15b, miR-34b, and miR-122, p<0.001) in sperm and in seminal plasma. This is the first study to demonstrate differences between sperm and seminal plasma miRNA expression level and to identify a correlation between the sperm concen- tration and miRNAs expression level. Therefore, these MiRNAs could have the potential be used as non-invasive biomarkers to diagnose males with impaired sperm production.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban male infertility sperm microRNA gene expression
Megjelenés:	Human Fertility. - 23 : 4 (2020), p. 246-255. -
További szerzők:	Molnár Zsuzsanna (1980-) (szülész-nőgyógyász, labor szakorvosjelölt, urológus) Tóthné Varga Emese Bodnár Béla Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Bálint Bálint László (1971-) (kutató orvos) Balogh István (1972-) (molekuláris biológus, genetikus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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