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001-es BibID:	BIBFORM077465
Első szerző:	Clemens Béla (neurológus)
Cím:	Inter-ictal network of focal epilepsy and effects of clinical factors on network activity / Béla Clemens, Johanna Dömötör, Miklós Emri, Szilvia Puskás, István Fekete
Dátum:	2019
ISSN:	1388-2457
Megjegyzések:	OBJECTIVE: Aim of the study was to explore the inter-ictal, resting-state EEG network in patients with focal epilepsy (FE) and to specify clinical factors that influence network activity. METHODS: Functional EEG connectivity (EEGfC) differences were computed between 232 FE patients (FE group) and 77 healthy controls. EEGfC was computed among 23 cortical regions within each hemisphere, for 25 very narrow bands from 1 to 25?Hz. We computed independent effects for six clinical factors on EEGfC in the FE group, by ANOVA and post-hoc t-statistics, corrected for multiple comparisons by false discovery rate method. RESULTS: Robust, statistically significant EEGfC differences emerged between the FE and the healthy control groups. Etiology, seizure type, duration of the illness and antiepileptic treatment were independent factors that influenced EEGfC. Statistically significant results occurred selectively in one or a few very narrow bands and outlined networks. Most abnormal EEGfC findings occurred at frequencies that mediate integrative and motor activities. CONCLUSIONS: FE patients have abnormal resting-state EEGfC network activity. Clinical factors significantly modify EEGfC. SIGNIFICANCE: Delineation of the FE network and modifying factors can open the way for targeted investigations and introduction of EEGfC into epilepsy research and practice.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban EEG functional connectivity Epileptic network Focal epilepsy LORETA Source Correlation
Megjelenés:	Clinical Neurophysiology. - 130 : 2 (2019), p. 251-258. -
További szerzők:	Dömötör Johanna (1982-) (neurológus) Emri Miklós (1962-) (fizikus) Puskás Szilvia (1979-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter)
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