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001-es BibID:	BIBFORM077798
Első szerző:	Mensch Károly
Cím:	PCR Technique Assisting the Early Diagnosis of Human Papillomavirus : a retrospective clinical study / Karoly Mensch, Krisztina Szarka, Henrik Mensch, Adrienn Dobai, Zoltan Magyar, Mariana Pacurar, Aurel Claudiu Vartolomei, Daniela Manuc, Csaba Dobo Nagy
Dátum:	2018
Megjegyzések:	The number of oral cancers associated with Human Papillomavirus (HPV) infection is increasing worldwide.The purpose of this retrospective clinical trial is to investigate the relationship between genital and oral HPVinfection and to observe the possibilities of polymerase chain reaction (PCR) technique and the limitationsfor oral HPV infection. The results of genital and oral HPV screening of 34 female patients and their partner,and 14 single female patients were processed in a private practice in Budapest between 2012 and 2015.After brush-biopsy sampling, HPV DNA identification and typing were performed using PCR technique. All inall 164 samples were typed. HPV DNA was detected in 76 cases (48.20%). HPV was detected in 55 casesfrom the genital samples (67%), and in 21 cases from the oral samples (25.6%). Genital HPV infection wasstatistically significantly higher in women (79.2% vs 22,9%, p<0.001). Gender comparison of genital HPVinfection showed a statistically significant difference (79.2% for women, 50% for men, p = 0.006). In caseof genital HPV infection, the oral HPV infection of the same person is more frequent. In this study, the abovementioned difference is significant for women and not significant for men. HPV16 is the HPV genotypewhich was identified in the highest ratio(47.2%). PCR technique is capable of the detection of oral HPVinfection, but follow-up studies with higher case number , and questionnaire studies are needed to understandHPV transmission more accurately.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Revista De Chimie. - 69 : 10 (2018), p. 2781-2787. -
További szerzők:	Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus) Mensch Henrik Dobai Adrienn Magyar Zoltán Pacurar, Mariana Vartolomei, Aurel Claudiu Manuc, Daniela Dobó Nagy Csaba (1961-) (fogszakorvos)
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