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001-es BibID:	BIBFORM078607
035-os BibID:	(cikkazonosító)5 (WoS)000457124000003 (Scopus)85061664892
Első szerző:	Váradi Györgyi
Cím:	Structure and synthesis of antifungal disulfide β-strand proteins from filamentous fungi / Györgyi Váradi, Gábor K. Tóth, Gyula Batta
Dátum:	2018
ISSN:	2076-2607
Megjegyzések:	The discovery and understanding of the mode of action of new antimicrobial agents is extremely urgent, since fungal infections cause 1.5 million deaths annually. Antifungal peptides and proteins represent a significant group of compounds that are able to kill pathogenic fungi. Based on phylogenetic analyses the ascomycetous, cysteine-rich antifungal proteins can be divided into three different groups: Penicillium chrysogenum antifungal protein (PAF), Neosartorya fischeri antifungal protein 2 (NFAP2) and ?bubble-proteins" (BP) produced, for example, by P. brevicompactum. They all dominantly have β-strand secondary structures that are stabilized by several disulfide bonds. The PAF group (AFP antifungal protein from Aspergillus giganteus, PAF and PAFB from P. chrysogenum, Neosartorya fischeri antifungal protein (NFAP)) is the best characterized with their common β-barrel tertiary structure. These proteins and variants can efficiently be obtained either from fungi production or by recombinant expression. However, chemical synthesis may be a complementary aid for preparing unusual modifications, e.g., the incorporation of non-coded amino acids, fluorophores, or even unnatural disulfide bonds. Synthetic variants up to ca. 6-7 kDa can also be put to good use for corroborating structure determination. A short overview of the structural peculiarities of antifungal β-strand disulfide bridged proteins will be given. Here, we describe the structural propensities of some known antifungal proteins from filamentous fungi which can also be prepared with modern synthetic chemistry methods.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk structure antifungal protein chemical synthesis solid-phase peptide synthesis native chemical ligation disulfide bond NFAP2 PAF
Megjelenés:	Microorganisms. - 7 : 1 (2018), p. 1-10. -
További szerzők:	Tóth Gábor (Szeged) Batta Gyula (1953-) (molekula-szerkezet kutató)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00008 GINOP GINOP-2.3.2-15-2016-00014 GINOP GINOP-2.3.3-15-2016-00004 GINOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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