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001-es BibID:	BIBFORM078698
035-os BibID:	(WoS)000426143900011 (Scopus)85042377333
Első szerző:	Zhou, Benqing
Cím:	99mTc-Labeled RGD-Polyethylenimine Conjugates with Entrapped Gold Nanoparticles in the Cavities for Dual-Mode SPECT/CT Imaging of Hepatic Carcinoma / Benqing Zhou, Ruizhi Wang, Feng Chen, Lingzhou Zhao, Peng Wang, Xin Li, Bányai István, Qiang Ouyang, Xiangyang Shi, Mingwu Shen
Dátum:	2018
ISSN:	1944-8244
Megjegyzések:	We report the construction and characterization of 99mTc-labeled arginine-glycine-aspartic acid (RGD)-polyethylenimine (PEI) conjugates with entrapped gold nanoparticles in the cavities (RGD-99mTc-Au PENPs) for dual mode SPECT/CT imaging of an orthotopic hepatic carcinoma model. In this study, PEI was successively decorated with diethylenetriaminepentaacetic acid, polyethylene glycol (PEG), and PEGylated RGD segments, and was utilized as an effective nanoplatform to entrap Au NPs and to be labelled with 99mTc. We show that the designed RGD-99mTc-Au PENPs display desirable colloidal stability and radiostability, and cytocompatibility in the investigated concentration range, and can be specifically uptaken by ?v?3 integrin-overexpressing liver cancer cells in vitro. In vivo CT and SPECT imaging results indicate that the particles are able to be accumulated within an orthotopic hepatic carcinoma and display both CT and SPECT contrast enhancement in the tumor tissue. With the proven biocompatibility in vivo via histological examinations, the designed RGD-99mTc-Au PENPs may be potentially employed as an effective nanoprobe for highly efficient dual mode SPECT/CT imaging of various ?v?3 integrin-overexpressing tumors.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk gold nanoparticles 99mTc polyethylenimine SPECT/CT imaging hepatic carcinoma
Megjelenés:	ACS Applied Materials and Interfaces. - 10 : 7 (2018), p. 6146-6154. -
További szerzők:	Wang, Ruizhi Chen, Feng Zhao, Lingzhou Wang, Peng Li, Xin Bányai István (1953-) (vegyész) Ouyang, Qiang Shi, Xiangyang Shen, Mingwu
Pályázati támogatás:	GINOP-2.3.2-15-2016-00008 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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