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001-es BibID:	BIBFORM078705
035-os BibID:	(Scopus)85017203743 (WoS)000426631300007
Első szerző:	Nagy Tibor (vegyész)
Cím:	Rapid qualitative analysis of 2 flavonoids, rutin and silybin, in medical pills by direct analysis in real-time mass spectrometry (DART-MS) combined with in situ derivatization / Tibor Nagy, Ákos Kuki, Lajos Nagy, Miklós Zsuga, Sándor Kéki
Dátum:	2018
ISSN:	1076-5174
Megjegyzések:	Direct analysis in real-time mass spectrometry (DART-MS) with in situ silylation was used for the rapid analysis of the flavonoids silybin ((2R,3R)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin-6-yl]chroman-4-one) and rutin (quercetin-3-O-rutinoside). Three different derivatization reagents, hexamethyldisilazane/trimethylchlorosilane/pyridine (HMDS/TMCS/pyridine), N,O-bis(trimethylsilyl)acetamide/trimethylchlorosilane/N-trimethylsilyimidazole (BSA/TMCS/TMSI), and N,O-bis(trimethylsilyl)trifluoroacetamide/trimethylchlorosilane (BSTFA/TMCS), were applied. Silybin and rutin were detected with various degrees of silylation, and the formation of dimers with pyridine and imidazole was also observed. HMDS/TMCS/pyridine was the best choice for the DART-MS analysis of silybin, and BSA/TMCS/TMSI was the most effective for the detection of rutin. The effects of the DART source temperature on desorption, ionization, in-source fragmentation, dimer formation, and hydrolysis of the trimethylsilyl groups were also studied. In addition, the collision-induced dissociation properties of the derivatized silybin and rutin were explored. With our in situ silylation method, the derivatized bioactive compounds in intact medical pills could also be detected by DART-MS.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban direct analysis in real time mass spectrometry (DART-MS) flavonoid derivatives in situ derivatization silybin silylation
Megjelenés:	Journal of Mass Spectrometry. - 53 : 3 (2018), p. 240-246. -
További szerzők:	Kuki Ákos (1966-) (villamosmérnök) Nagy Lajos (1979-) (vegyész) Zsuga Miklós (1944-) (polimer kémikus) Kéki Sándor (1964-) (polimer kémikus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00041 GINOP GINOP-2.3.3-15-2016-00004 GINOP NKFI-116465 egyéb ÚNKP-16-3 egyéb
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