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001-es BibID:	BIBFORM078907
035-os BibID:	(WoS)000373072800058
Első szerző:	Soeberdt, Michael
Cím:	The lipophilic Echinacea purpurea root extract exhibit anti-inflammatory and anti-pruritic properties in vitro and in vivo / M. Soeberdt, A. Olah, U. Knie, T. Biro, S. Dähnhardt-Pfeiffer, C. Abels
Dátum:	2016
Megjegyzések:	Echinacea purpurea extracts (purple coneflower) are known to have immunemodulatory effects. Several alkamides, as the major lipophilic constituents, bind to cannabinoid receptors 1 and 2. Since the endocannabinoid system is of importance in inflammatory skin diseases, anti-inflammatory activity of alkamides was investigated. Therefore the new lipophilic root extract of Echinacea purpurea was tested in cultured human keratinocytes. A significant (P < 0.05) reduction of lipoteichoic acid-induced mRNA expression of IL-1a, IL-1b, and IL-6 was observed. Moreover, the mixture was also able to reduce expression of IL-8 and showed significant anti-inflammatory effects in vitro. The overall impact of the new developed water-in-oil (W/O) emulsion containing the new lipophilic root extract of Echinacea purpurea was investigated in different clinical studies. Long-term efficacy and safety of the Echinacea purpurea root extract (W/O) emulsion was evaluated in a 3 month half-side trial against comparator (30.2 15.9 years; n = 60). The emulsions were applied at least twice daily on two comparable and contralateral located skin areas on the crooks of arms, hollow of the knees, on the trunk, on the wrist or on the shin with slight lesions of atopic dermatitis. Erythema reduced significantly after 1, 2 and 3 months after application of Echinacea purpurea root extract (W/O) emulsion, as well as comparator. Interestingly, Echinacea purpurea root extract (W/O) emulsion is superior after prolonged application, indicated by a significant difference to comparator after 2 and 3 months. A significant reduction of pruritus could be measured after 1, 2 and 3 months. Furthermore Echinacea purpurea root extract (W/O) emulsion was significant superior compared to comparator after 2 months and nearly significant after 3 months. The same was observed for the local SCORAD. A significant reduction could be measured after 1, 2 and 3 months. Furthermore Echinacea purpurea root extract (W/O) emulsion was significant superior compared to comparator after 3 months. To gain further insight in underlying mechanisms, electron microscope analyses of the skin barrier as well as the lipid analysis by HPTLC will be performed and data will be presented. In summary, application of an Echinacea purpurea root extract (W/O) emulsion reduced significantly the local SCORAD, erythema and pruritus without irritation, very likely by improved functions of the epidermal barrier.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk Echinacea purpurea inflammation pruritus
Megjelenés:	Experimental Dermatology. - 25 : 3 (2016), p. E10. -
További szerzők:	Oláh Attila (1984-) (élettanász) Knie, Ulrich Bíró Tamás (1968-) (élettanász) (absztraktok) Dähnhardt-Pfeiffer, Stephan Abels, Christoph
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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