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001-es BibID:	BIBFORM079551
035-os BibID:	(Scopus)85029739412 (WOS)000412754700010 (PMID)28939958
Első szerző:	Hermenean, Anca
Cím:	Biochemical, Histopathological and Molecular Responses in Gills of Leuciscus cephalus Exposed to Metals / Anca Hermenean, Georgiana Gheorghiu, Miruna Silvia Stan, Hildegard Herman, Bianca Onita, Doru Puiu Ardelean, Aurel Ardelean, Mihály Braun, Miklós Zsuga, Sándor Kéki, Marieta Costache, Anca Dinischiotu
Dátum:	2017
ISSN:	0090-4341
Megjegyzések:	Gills are major targets for acute metal toxicity in fish, due to their permanent contact with aquatic pollutants. To assess the effects of metals on gills of the Leuciscus cephalus (chub), fish individuals were collected from two sites in the Tur River, Romania, in upstream (site 1) and downstream (site 2) of a metal pollution source. Quantitative and hyperspectral analyses showed that Zn, Sr, and Fe concentrations were significantly higher in gills from site 2 compared with site 1. Malondialdehyde and advanced oxidation protein products levels increased 17 and 28%, respectively, whereas reduced glutathione level diminished significantly in the gills of fish collected from site 2 compared to site 1. The activities of superoxide dismutase, catalase, and glutathione-S-transferase increased significantly at 41, 21, and 28%, respectively. Proliferating cell nuclear antigen (PCNA) protein levels, as well as the amount of DNA damage, were significantly increased for site 2 compared with site 1. The induced oxidative stress generated hyperplasia, hypertrophy, and inflammation in the epithelial cells and apoptosis. Hence, this could suggest that gill cells have tried to counteract the oxidative stress-induced DNA fragmentation by PCNA upregulation, but the PCNA expression decreased on longer time due to the low level of GSH, resulting in apoptosis.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Archives Of Environmental Contamination And Toxicology. - 73 : 4 (2017), p. 607-618. -
További szerzők:	Gheorghiu, Georgiana Stan, Miruna Herman, Hildegard Onita, Bianca Puiu Ardelean, Doru Ardelean, Aurel Braun Mihály (1966-) (vegyész, analitikus) Zsuga Miklós (1944-) (polimer kémikus) Kéki Sándor (1964-) (polimer kémikus) Costache, Marieta Dinischiotu, Anca
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