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001-es BibID:	BIBFORM080262
035-os BibID:	(PMID)31369737 (WOS)000508449700038 (Scopus)85073551530
Első szerző:	Szabó Imre Lőrinc (általános orvos)
Cím:	The phytocannabinoid (-)-cannabidiol (CBD) operates as a complex, differential modulator of human hair growth : anti-inflammatory submicromolar versus hair growth inhibitory micromolar effects / Imre Lőrinc Szabó, Erika Herczeg-Lisztes, Gabriella Béke, Kinga Fanni Tóth, Ralf Paus, Attila Oláh, Tamás Bíró
Dátum:	2020
ISSN:	0022-202X 1523-1747
Megjegyzések:	We have previously shown that the endocannabinoid anandamide and the phytocannabinoid ( )-?9-trans-tetrahydrocannabinol reduce hair shaft elongation via promoting catagen in a CB1 receptor-dependent manner. By using microdissected human scalp hair follicles (HFs), as well as cultured primary human outer root sheath keratinocytes (ORSKs), now we assessed the effects of the non-psychotropic phytocannabinoid ( )-cannabidiol (CBD), which does not activate CB1, but exerts complex anti-acne effects in sebocytes, and is currently being investigated in a phase II clinical trial in moderate to severe acne. We found that 0.1 ?M CBD promoted hair shaft production, and suppressed Toll-like receptor 3 activation-induced pro-inflammatory response of cultured ORSKs in an adenosine receptor-dependent manner, whereas at 10 ?M it suppressed HF growth, which was accompanied by the induction of premature catagen entry. Importantly, potent pro-catagen concentrations of CBD induced Ca2+-influx to ORSKs via the mostly Ca2+-permeable TRPV4 ion channels, activation of which was recently demonstrated to induce premature catagen entry (Szabó et al. JID, 2018). Thus, data of this pilot, exploratory study invite the hypothesis that low, adenosine receptor-activating doses of CBD could become useful as adjunct therapy for inflammatory hair loss disorders, whereas high-dose, TRPV4-activating CBD is an attractive candidate inhibitor of unwanted hair growth.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk hair growth (-)-cannabidiol TRPV4 adenosine receptor anagen catagen anti-inflammatory
Megjelenés:	Journal Of Investigative Dermatology. - 140 : 2 (2020), p. 484-488.e5. -
További szerzők:	Lisztes Erika (1986-) (élettanász) Béke Gabriella (1987-) (molekuláris biológus) Tóth Kinga Fanni (1992-) (molekuláris biológus, élettanász) Paus, Ralf Oláh Attila (1984-) (élettanász) Bíró Tamás (1968-) (élettanász)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00015 GINOP NKFIH-120552 NKFIH NKFIH-121360 NKFIH NKFIH-125055 NKFIH ÚNKP-18-4-DE-247 Egyéb NTP-NFTÖ-18-B-0168 Egyéb EU's Horizon 2020 research and innovation fund No. 739593 Egyéb
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