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001-es BibID:	BIBFORM080523
Első szerző:	Devi, Sagarika
Cím:	Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001 / Sagarika Devi, Heiko T. Kiesewalter, Renátó Kovács, Jens Christian Frisvad, Tilmann Weber, Thomas Ostenfeld Larsen, Ákos T. Kovács, Ling Ding
Dátum:	2019
ISSN:	2405-805X
Megjegyzések:	For a safe and sustainable environment, effective microbes as biocontrol agents are in high demand. We have isolated a new Bacillus velezensis strain DTU001, investigated its antifungal spectrum, sequenced its genome, and uncovered the production of lipopeptides in HPLC-HRMS analysis. To test the antifungal efficacy, extracts of B. velezensis DTU001 was tested against a range of twenty human or plant pathogenic fungi. We demonstrate that inhibitory potential of B. velezensis DTU001 against selected fungi is superior in comparison to single lipopeptide, either iturin or fengycin. The isolate showed analogous biofilm formation to other closely related Bacilli. To further support the biocontrol properties of the isolate, coculture with Candida albicans demonstrated that B. velezensis DTU001 exhibited excellent antiproliferation effect against C. albicans. In summary, the described isolate is a potential antifungal agent with a broad antifungal spectrum that might assist our aims to avoid hazardous pathogenic fungi and provide alternative to toxicity caused by chemicals.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Synthetic and Systems Biotechnology. - 4 : 3 (2019), p. 142-149. -
További szerzők:	Kiesewalter, Heiko T. Kovács Renátó László (1987-) (molekuláris biológus) Frisvad, Jens Christian Weber, Tilmann Larsen, Thomas Ostenfeld Kovács Ákos T. Ding, Ling
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