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001-es BibID:	BIBFORM080774
035-os BibID:	(WOS)000540615800031 (Scopus)85072051353 (PMID)31506802
Első szerző:	Pál Ildikó (belgyógyász szakorvos)
Cím:	The Impact of Beta-Catenin and glutathione-S-transferase Gene Polymorphisms on the Treatment Results and Survival of Multiple Myeloma Patients / Ildikó Pál, Bernadett Szilágyi, Béla Nagy Jr., Tibor Pál, Katalin Hodosi, Árpád Illés, László Váróczy
Dátum:	2020
ISSN:	1219-4956 1532-2807
Megjegyzések:	Multiple myeloma (MM) is an incurable disease, however, novel therapeutic agents has significantly improved its prognosis. In this study we analyzed if polymorphisms in the genes of β-catenin and glutathione-S-transferase have affected the clinical course, treatment response and progression-free survival (PFS) of MM patients. Ninety-seven MM patients were involved who were administered immunomodulatory drug (Imid) or alkylating agent-based therapy. β-catenin (CTNNB1, rs4135385 A?>?G, rs4533622 A?>?C) and glutathione-S-transferase (GSTP1 105, GSTP1 114) gene polymorphisms were analyzed by Light SNiP assays. The distribution of CTNNB1 (rs4135385) AA, AG and GG genotypes were 48.4%, 47.4% and 4,1%, respectively. Patients with AA genotype were older than those who carried G allele (64.5 vs. 61.0 years of age, p?<?0.05). Response to Imid-based therapies (p?<?0.05) and PFS (p?=?0.032) were significantly more favourable in the AA homozygous group. The other polymorphism (rs4533622) of β-catenin gene did not markedly influence these clinical parameters, although MM was diagnosed at significantly younger age in subjects with CC genotype compared to AG/AA combined genotypes (59.1 vs. 65.7 years, p?=?0.015). When GSTP1 polymorphisms were investigated, no such significant associations were observed. Our results demonstrate that the polymorphism of β-catenin gene (rs4135385) may be an independent predictive factor in MM.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cereblon Glutathione-S-transferase Multiple myeloma Personalized treatment Polymorphism β-catenin
Megjelenés:	Pathology & Oncology Research. - 26 : 3 (2020), p. 1633-1638. -
További szerzők:	Szilágyi Bernadett (1993-) Nagy Béla Jr. (1980-) (labordiagnosztikai szakorvos) Pál Tibor Hódosi Katalin Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Váróczy László (1974-) (belgyógyász, haematológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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