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001-es BibID:	BIBFORM081363
035-os BibID:	(cikkazonosító)fow037 (WoS)000377481300008 (Scopus)84973098761
Első szerző:	Bellasio, Martina
Cím:	Complete genome sequence and transcriptome regulation of the pentose utilizing yeast Sugiyamaella lignohabitans / Martina Bellasio, Armin Peymann, Matthias G. Steiger, Minoska Valli, Matthias Sipiczki, Michael Sauer, Alexandra B. Graf, Hans Marx, Diethard Mattanovich
Dátum:	2016
ISSN:	1567-1356 1567-1364
Megjegyzések:	Efficient conversion of hexoses and pentoses into value-added chemicals represents one core step for establishing economically feasible biorefineries from lignocellulosic material. While extensive research efforts have recently provided advances in the overall process performance, the quest for new microbial cell factories and novel enzymes sources is still open. As demonstrated recently the yeast Sugiyamaella lignohabitans (formerly Candida lignohabitans) represents a promising microbial cell factory for the production of organic acids from lignocellulosic hydrolysates. We report here the de novo genome assembly of S. lignohabitans using the Single Molecule Real-Time platform, with gene prediction refined by using RNA-seq. The sequencing revealed a 15.98 Mb genome, subdivided into four chromosomes. By phylogenetic analysis, Blastobotrys (Arxula) adeninivorans and Yarrowia lipolytica were found to be close relatives of S. lignohabitans. Differential gene expression was evaluated in typical growth conditions on glucose and xylose and allowed a first insight into the transcriptional response of S. lignohabitans to different carbon sources and different oxygenation conditions. Novel sequences for enzymes and transporters involved in the central carbon metabolism, and therefore of potential biotechnological interest, were identified. These data open the way for a better understanding of the metabolism of S. lignohabitans and provide resources for further metabolic engineering.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Sugiyamaella lignohabitans complete genome sequence RNA-Seq SMRT sequencing microbial cell factory
Megjelenés:	FEMS Yeast Research. - 16 : 4 (2016), p. 1-14. -
További szerzők:	Peymann, Armin Steiger, Matthias G. Valli, Minoska Sipiczki Mátyás (1948-) (biológus) Sauer, Michael Graf, Alexandra B. Marx, Hans Mattanovich, Diethard
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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