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001-es BibID:	BIBFORM081479
Első szerző:	Ruzsics István
Cím:	L-Arginine Pathway in COPD Patients with Acute Exacerbation : A New Potential Biomarker / István Ruzsics, Lajos Nagy, Sándor Kéki, Veronika Sárosi, Balázs Illés, Zsolt Illés, Ildikó Horváth, Lajos Bogár, Tihamér Molnár
Dátum:	2016
ISSN:	1541-2555 1541-2563
Megjegyzések:	Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mortality. Clinical criteria of AECOPD are subjective. Biomarkers for AECOPD may aid in the initiation of early treatment. Increased production of asymmetric and symmetric dimethylarginine (ADMA, SDMA) is related to hypoxia. In COPD, a rise in ADMA results in a shift of L-arginine breakdown, contributing to airway obstruction. We aimed to compare serum levels of ADMA, SDMA and L-arginine in patients with and without AECOPD. Methods: L-arginine metabolites quantifi ed by high-performance liquid chromatography in venous blood samples and partial capillary oxygen pressure were prospectively investigated in 32 patients with COPD, 12 with AECOPD and 30 healthy subjects. Results: Both ADMA and SDMA were signifi cantly higher in AECOPD compared to stable COPD (p = 0.004 and p < 0.001, respectively). Oxygen content in capillaries correlated with serum ADMA concentration. However, the concentration of L-arginine was not different between AECOPD and stable COPD. Both ADMA and SDMA separated AECOPD with high sensitivity and specifi city (AUC: 0.81, p = 0.001; AUC: 0.91, p < 0.001, respectively). A cut-off value ?0.57 for SDMA was an independent variable to confi rm AECOPD in a regression model (OR: 1.632, p = 0.001). All markers were signifi cantly higher in the sera of both patient groups compared to the controls (p < 0.05, respectively). Conclusions: COPD is associated with elevated L-arginine, ADMA and SDMA serum levels. In patients with AECOPD, production of ADMA and SDMA are more pronounced presumably due to more severe hypoxic insult. Methylated arginine derivatives in the sera may help early recognition of AECOPD.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk asymmetric and symmetric dimethylarginine chronic obstructive pulmonary disease L-arginine
Megjelenés:	COPD Journal of Chronic Obstructive Pulmonary Disease. - 13 : 2 (2016), p. 139-145. -
További szerzők:	Nagy Lajos (1979-) (vegyész) Kéki Sándor (1964-) (polimer kémikus) Sárosi Veronika Illés Miklós Balázs Illés Zsolt (neurológus, Pécs) Horváth Ildikó (1964-) (tüdőgyógyász) Bogár Lajos Molnár Tihamér (1992-) (általános orvos)
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