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001-es BibID:	BIBFORM081578
035-os BibID:	(PMID)30963976
Első szerző:	Muscogiuri, Giovanna
Cím:	Calcium and Vitamin D Supplementation : myths and Realities with Regard to Cardiovascular Risk / Giovanna Muscogiuri, Luigi Barrea, Barbara Altieri, Carolina Di Somma, Harjit Pal Bhattoa, Daniela Laudisio, Guillaume T. Duval, Gabriella Pugliese, Cédric Annweiler, Francesco Orio, Hana Fakhouri, Silvia Savastano, Annamaria Colao
Dátum:	2019
ISSN:	1570-1611
Megjegyzések:	Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of the intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Vitamin D bone health calcium cardiovascular system myocardial infarction stroke
Megjelenés:	Current Vascular Pharmacology. - 17 : 6 (2019), p. 610-617. -
További szerzők:	Barrea, Luigi Altieri, Barbara Di Somma, Carolina Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Laudisio, Daniela Duval, Guillaume Pugliese, Gabriella Annweiler, Cedric Orio, Francesco Fakhoury, Hana M. A. Savastano, Silvia Colao, Annamaria
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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