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001-es BibID:	BIBFORM082386
035-os BibID:	(WoS)000528101100002 (Scopus)85084051209
Első szerző:	Ashton, Nicholas J.
Cím:	An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders / Nicholas J. Ashton, Abdul Hye, Anto P. Rajkumar, Antoine Leuzy, Stuart Snowden, Marc Suárez-Calvet, Thomas K. Karikari, Michael Schöll, Renaud La Joie, Gil D. Rabinovici, Kina Höglund, Clive Ballard1, Tibor Hortobágyi, Per Svenningsson, Kaj Blennow, Henrik Zetterberg, Dag Aarsland
Dátum:	2020
ISSN:	1471-003X 1471-0048
Megjegyzések:	In recent years, there has been an increasing emphasis on the importance of blood-based biomarkers in the first-in-line evaluation of patients with suspected neurodegenerative disorders (NDD). While neuroimaging (structural and molecular) and cerebrospinal fluid (CSF) analyses identify the underlying pathophysiology at the earliest stage, a biologically relevant marker derived from blood would have greater utility in the primary care setting and in the early screening for eligibility for therapeutic trials. The rapid advancement of ultra-sensitive assays has enabled the investigation of pathological proteins to be measured in blood samples, but research has been predominately focused on Alzheimer's disease (AD) cohorts. Nonetheless, proteins that are currently under scrutiny as blood biomarker candidates for AD (amyloid-?, tau and neurofilament light chain) are likely to have importance for Lewy body dementia's (LBD), frontotemporal dementia's (FTD) and other NDDs in terms of shared pathologies, similar degenerative processes or in the differential diagnosis of clinical symptoms. This review gives an overview and update on the current state of blood-based biomarkers for non-AD NDD, focusing on how candidate AD and novel biomarkers perform in these populations. As background information, we also briefly outline the neuropathological, clinical, molecular imaging and CSF features of the most common NDDs outside of the AD continuum.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Nature Reviews Neuroscience. - 16 : 5 (2020), p. 265-284. -
További szerzők:	Hye, Abdul Rajkumar, Anto P. Leuzy, Antoine Snowden, Stuart Suárez-Calvet, Marc Karikari, Thomas K. Schöll, Michael La Joie, Renaud Rabinovici, Gil D. Höglund, Kina Ballard, Clive G. Hortobágyi Tibor (1965-) (patológus) Svenningsson, Per Blennow, Kaj Zetterberg, Henrik Aarsland, Dag
Pályázati támogatás:	(2017-1.2.1-NKP-2017-00002) Egyéb
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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