Találati lista | Tudóstér

001-es BibID:	BIBFORM082672
035-os BibID:	(cikkazonosító)1202 (WoS)000487293600001 (Scopus)85072974153
Első szerző:	Szentesi Andrea
Cím:	Multiple Hits in Acute Pancreatitis : Components of Metabolic Syndrome Synergize Each Other's Deteriorating Effects / Andrea Szentesi, Andrea Párniczky, Áron Vincze, Judit Bajor, Szilárd Gódi, Patricia Sarlós, Noémi Gede, Ferenc Izbéki, Adrienn Halász, Katalin Márta, Dalma Dobszai, Imola Török, Hunor Farkas, Mária Papp, Márta Varga, József Hamvas, János Novák, Artautas Mickevicius, Elena Ramirez Maldonado, Ville Sallinen, Dóra Illés, Balázs Kui, Bálint Erőss, László Czakó, Tamás Takács, Péter Jr. Hegyi, Hungarian Pancreatic Study Group
Dátum:	2019
ISSN:	1664-042X
Megjegyzések:	Introduction: The incidence of acute pancreatitis (AP) and the prevalence of metabolic syndrome (MetS) are growing worldwide. Several studies have confirmed that obesity (OB), hyperlipidemia (HL), or diabetes mellitus (DM) can increase severity, mortality, and complications in AP. However, there is no comprehensive information on the independent or joint effect of MetS components on the outcome of AP. Our aims were (1) to understand whether the components of MetS have an independent effect on the outcome of AP and (2) to examine the joint effect of their combinations. Methods: From 2012 to 2017, 1435 AP cases from 28 centers were included in the prospective AP Registry. Patient groups were formed retrospectively based on the presence of OB, HL, DM, and hypertension (HT). The primary endpoints were mortality, severity, complications of AP, and length of hospital stay. Odds ratio (OR) with 95% confidence intervals (CIs) were calculated. Results: 1257 patients (55.7 ? 17.0 years) were included in the analysis. The presence of OB was an independent predictive factor for renal failure [OR: 2.98 (CI: 1.33?6.66)] and obese patients spent a longer time in hospital compared to non-obese patients (12.1 vs. 10.4 days, p = 0.008). HT increased the risk of severe AP [OR: 3.41 (CI: 1.39?8.37)], renal failure [OR: 7.46 (CI: 1.61?34.49)], and the length of hospitalization (11.8 vs. 10.5 days, p = 0.020). HL increased the risk of local complications [OR: 1.51 (CI: 1.10?2.07)], renal failure [OR: 6.4 (CI: 1.93?21.17)], and the incidence of newly diagnosed DM [OR: 2.55 (CI: 1.26?5.19)]. No relation was found between the presence of DM and the outcome of AP. 906 cases (mean age ? SD: 56.9 ? 16.7 years) had data on all four components of MetS available. The presence of two, three, or four MetS factors increased the incidence of an unfavorable outcome compared to patients with no MetS factors. Conclusion: OB, HT, and HL are independent risk factors for a number of complications. HT is an independent risk factor for severity as well. Components of MetS strongly synergize each other's detrimental effect. It is important to search for and follow up on the components of MetS in AP.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk acute pancreatitis metabolic syndrome obesity diabetes mellitus hypertension hyperlipidemia severity mortality
Megjelenés:	Frontiers in Physiology. - 10 (2019), p. 1-13. -
További szerzők:	Párniczky Andrea (gyermekgyógyász) Vincze Áron Bajor Judit Gódi Szilárd Sarlós Patrícia Gede Noémi Izbéki Ferenc Halász Adrienn Márta Katalin Dobszai Dalma Török Imola Farkas Hunor Papp Mária (1975-) (belgyógyász, gasztroenterológus) Varga Márta Hamvas József Novák János Mickevicius, Artautas Maldonado, Elena Ramirez Sallinen, Ville Illés Dóra Kui Balázs Erőss Bálint Czakó László Takács Tamás (Szeged) Hegyi Péter Jr. (belgyógyász) Hungarian Pancreatic Study Group
Pályázati támogatás:	KH125678 Egyéb K116634 Egyéb K120335 Egyéb K128222 Egyéb GINOP 2.3.2-15-2016-00048 GINOP EFOP-3.6.2-16-2017-00006 EFOP LP2014-10/2014 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: