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001-es BibID:	BIBFORM083852
035-os BibID:	(WoS)000514846600012 (Scopus)85079416349
Első szerző:	Dogra, Pranay
Cím:	Tissue Determinants of Human NK Cell Development, Function, and Residence / Pranay Dogra, Chiara Rancan, Wenji Ma, Marta Toth, Takashi Senda, Dustin J. Carpenter, Masaru Kubota, Rei Matsumoto, Puspa Thapa, Peter A. Szabo, Maya Meimei Li Poon, Jacky Li, Janice Arakawa-Hoyt, Yufeng Shen, Lawrence Fong, Lewis L. Lanier, Donna L. Farber
Dátum:	2020
ISSN:	0092-8674
Megjegyzések:	Immune responses in diverse tissue sites are critical for protective immunity and homeostasis. Here, we investigate how tissue localization regulates the development and function of human natural killer (NK) cells, innate lymphocytes important for anti-viral and tumor immunity. Integrating high-dimensional analysis of NK cells from blood, lymphoid organs, and mucosal tissue sites from 60 individuals, we identify tissue-specific patterns of NK cell subset distribution, maturation, and function maintained across age and between individuals. Mature and terminally differentiated NK cells with enhanced effector function predominate in blood, bone marrow, spleen, and lungs and exhibit shared transcriptional programs across sites. By contrast, precursor and immature NK cells with reduced effector capacity populate lymph nodes and intestines and exhibit tissue-resident signatures and site-specific adaptations. Together, our results reveal anatomic control of NK cell development and maintenance as tissue-resident populations, whereas mature, terminally differentiated subsets mediate immunosurveillance through diverse peripheral sites.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk NK cells
Megjelenés:	Cell. - 180 : 4 (2020), p. 749-763. -
További szerzők:	Rancan, Chiara Ma, Wenji Tóth Márta (1986-) (biológus) Senda, Takashi Carpenter, Dustin J. Kubota, Masaru Matsumoto, Rei Thapa, Puspa Szabó Péter András Li Poon, Maya Meimei Li, Jacky Arakawa-Hoyt, Janice Shen, Yufeng Fong, Lawrence Lanier, Lewis L. Farber, Donna L.
Pályázati támogatás:	3.4.2-VEKOP-15-2015-00001 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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