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001-es BibID:	BIBFORM084572
Első szerző:	Todea, Anamaria
Cím:	Biocatalytic synthesis of delta-gluconolactone and epsilon-caprolactone copolymers / Anamaria Todea, Valentin Badea, Nagy Lajos, Kéki Sándor, Carmen G. Boeriu, Francisc Péter
Dátum:	2014
ISSN:	0001-527X 1734-154X
Megjegyzések:	The biodegradability and biocompatibility properties of epsilon-caprolactone homopolymers place it as a valuable raw material, particularly for controlled drug delivery and tissue engineering applications. However, the usefulness of such materials is limited by their low hydrophilicity and slow biodegradation rate. In order to improve polycaprolactone properties and functionalities, copolymerization of epsilon-caprolactone with delta-gluconolactone was investigated. Since enzymatic reactions involving sugars are usually hindered by the low solubility of these compounds in common organic solvents, finding the best reaction medium was a major objective of this research. The optimal copolymerization conditions were set up by using different organic media (solvent and solvents mixtures), as well as solvent free systems that are able to dissolve (completely or partially) sugars, and are nontoxic for enzymes. Native and immobilized lipases by different immobilization techniques from Candida antarctica B and Thermomyces lanuginosus have been used as biocatalyst at 80 degrees C. Although the main copolymer amount was synthesized in DMSO:t-BuOH (20:80) medium, the highest polymerization degrees, up to 16 for the copolymer product, were achieved in solventless conditions. The products, cyclic and linear polyesters, have been characterized by FT-IR and MALDI-TOF MS analysis. The reaction product analysis revealed the formation of cyclic products that could be the major impediment of further increase of the chain length
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk ?-caprolactone d-gluconolactone lipases biopolymers
Megjelenés:	Acta Biochimica Polonica. - 61 : 2 (2014), p. 205-2010. -
További szerzők:	Badea, Valentin Nagy Lajos (1979-) (vegyész) Kéki Sándor (1964-) (polimer kémikus) Boeriu, Carmen G. Francisc Péter
Pályázati támogatás:	POSDRU/159/1.5/S/137070 Egyéb
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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