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001-es BibID:	BIBFORM084978
Első szerző:	Dobi Deján
Cím:	Peritubular capillary basement membrane multilayering in early and advanced transplant glomerulopathy : quantitative parameters and diagnostic aspects / Dobi Deján, Bodó Zsolt, Kemény Éva, Bidiga László, Hódi Zoltán, Szenohradszky Pál, Szederkényi Edit, Szilvási Anikó, Iványi Béla
Dátum:	2016
ISSN:	0945-6317
Megjegyzések:	The ultrastructural quantitative aspects of peritubular capillary basement membrane multilayering (PTCBML) were examined in 57 kidney transplant biopsies with transplant glomerulopathy (TG). The measurements included three cutoffs [permissive: 1 PTC with 5 basement membrane (BM) layers, intermediate: 3 PTCs with 5 layers or 1 PTC with 7 layers, strict: 1 PTC with 7 layers and 2 PTCs with 5 layers] and the mean number of BM layers (PTCcirc). Two groups were assigned, namely patients with mild TG (Banff cg1a and cg1b) and those with moderate-to-severe TG (cg2 and cg3). Their respective clinical, serological, and morphological characteristics were then compared. The clinical data revealed that mild TG corresponded to early chronic antibodymediated rejection (cABMR), while moderate-to-severe TG corresponded to the advanced stage of the disease. The permissive threshold displayed the lowest specificity (73 %) and the highest sensitivity (83 %) for moderate-to-severe TG, and its corresponding PTCcirc value was 3 layers. In contrast, the strict threshold?adopted by the Banff 2013 classification? displayed a specificity and sensitivity of 93 and 52 %, respectively, and the corresponding PTCcirc was 4 layers. In mild TG, 26 % of the cases met the permissive cutoff and 6 % the strict cutoff. Mild TG was associated with a lower PTCcirc (2.6 layers vs 4.5 layers in moderate-to-severe TG; p < 0.0001). Amongst the various criteria, the permissive criterion was associated most frequently with mild TG, and had prognostic relevance. Because of this, we propose its usage as a marker of early cABMR-induced PTCBML if non-alloimmune causes of PTCBML can be ruled out.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Renal transplantation Chronic antibody-mediated rejection Peritubular capillaries
Megjelenés:	Virchows Archiv. - 469 : 5 (2016), p. 563-573. -
További szerzők:	Bodó Zsolt Kemény Éva Bidiga László (1977-) (patológus) Hódi Zoltán Szenohradszky Pál Szederkényi Edit Szilvási Anikó (1977-) (molekuláris biológus) Iványi Béla (orvos, Szeged)
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