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001-es BibID:	BIBFORM085460
035-os BibID:	(WOS)000412737500010 (Scopus)85020091346
Első szerző:	Tarantini, Stefano
Cím:	Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer's disease using functional laser speckle contrast imaging / Tarantini Stefano, Fulop Gabor A., Kiss Tamas, Farkas Eszter, Zölei-Szénási Dániel, Galvan Veronica, Toth Peter, Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy
Dátum:	2017
ISSN:	2509-2715 2509-2723
Megjegyzések:	Increasing evidence from epidemiological, clinical, and experimental studies indicates that cerebromicrovascular dysfunction and microcirculatory damage play critical roles in the pathogenesis of many types of dementia in the elderly, including both vascular cognitive impairment (VCI) and Alzheimer's disease. Vascular contributions to cognitive impairment and dementia (VCID) include impairment of neurovascular coupling responses/functional hyperemia (Bneurovascular uncoupling^). Due to the growing interest in understanding and pharmacologically targeting pathophysiological mechanisms of VCID, there is an increasing need for sensitive, easy-to-establish methods to assess neurovascular coupling responses. Laser speckle contrast imaging (LSCI) is a technique that allows rapid and minimally invasive visualization of changes in regional cerebromicrovascular blood perfusion. This type of imaging technique combines high resolution and speed to provide great spatiotemporal accuracy to measure moment-to-moment changes in cerebral blood flow induced by neuronal activation. Here, we provide detailed protocols for the successful measurement in neurovascular coupling responses in anesthetized mice equipped with a thinned-skull cranial window using LSCI. This method can be used to evaluate the effects of anti-aging or anti-AD treatments on cerebromicrovascular health.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Neurovascular coupling Functional hyperemia Laser speckle contrast imaging Laser speckle contrast analysis LASCA Laser speckle imaging LSI
Megjelenés:	GeroScience. - 39 : 4 (2017), p. 465-473. -
További szerzők:	Fülöp Gábor Áron (1988-) (általános orvos) Kiss Tamás Farkas Eszter Zölei-Szénási Dániel Galvan, Veronica Tóth Péter (sebész) Csiszár Anna Ungvári Zoltán Yabluchanskiy, Andriy
Pályázati támogatás:	K111923 OTKA EFOP-3.6.1-16- 2016-00008 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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