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001-es BibID:	BIBFORM085819
Első szerző:	Zima Endre (kardiológus)
Cím:	Endothelin-1-induced elevations in purine metabolite concentrations - autoregulatory protection in the canine pericardium? / Endre Zima, Violetta Kékesi, Andrea Nagy, László Losonczi, Ildikó Toma, Pál Soós, Erzsébet Barát, Éva Huszár, Bela Merkely, Ferenc Horkay, Alexander Juhász-Nagy
Dátum:	2002
ISSN:	0143-5221
Megjegyzések:	Pericardial fluid accumulates the cardioprotective purine metabolites, as well as the endogenous vasoconstrictor agent endothelin-1 (ET-1). The aim of the present study was to characterize the pericardial concentrations of the purine metabolites adenosine, inosine and hypoxanthine before and after intrapericardial administration of ET-1 to the in situ heart. The closed pericardial sac of anaesthetized dogs (n?9) was cannulated for ET-1 administration and for obtaining native pericardial fluid and control pericardial infusate samples (C1 and C2), as well as consecutive pericardial infusate samples (samples I, II and III) obtained 15 min after intrapericardial administration of 150 pmol/kg ET-1. In an additional five dogs, using the same protocol, ventricular epicardial and endocardial monophasic action potential recordings were performed to assess local ischaemic electrophysiological changes. Significant elevations of pericardial purine metabolite concentrations (measured by HPLC) were found in sample II compared with sample C2: adenosine, 4.5?1.7 compared with 0.5?0.1 ?M (P!0.05); inosine, 18.3?2.8 compared with 0.9?0.2 ?M (P!0.001); hypoxanthine, 38.1?8.0 compared with 13.4?2.6 ?M (P!0.01). Systemic blood pressure, left ventricular pressure and contractility, and systemic plasma levels of the purine metabolites remained unchanged during the ET-1 effect, while significant ECG ST elevations (STmax 0.68?0.01 mV; P!0.001) were observed. In the five dogs analysed electrophysiologically, the left ventricular epicardial monophasic action potential duration and upstroke velocity decreased significantly at time point II compared with C2,while the endocardial monophasic action potential duration and upstroke velocity did not show ischaemia-related changes. The results suggest that intrapericardial administration of ET-1 induces subepicardial ischaemia, with parallel activation of coronary metabolic adaptive and cardiac self-protective mechanisms in the epimyocardial layer of the heart.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok konferenciacikk folyóiratcikk adenosine autoregulation endothelin-1 inosine ischaemia pericardium
Megjelenés:	Clinical Science. - 103 : Suppl. 48 (2002), p. 202S-205S. -
További szerzők:	Kékesi Violetta Nagy Andrea Losonczi László (1941-) (matematikus) Toma Ildikó Soós Pál Barát Erzsébet Huszár Éva Merkely Béla (1965-) (orvos) Horkay Ferenc Juhász-Nagy Alexander
Pályázati támogatás:	T034417 OTKA T035144 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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