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001-es BibID:	BIBFORM086958
035-os BibID:	(WoS)000548924800004 (Scopus)85087474643 (PubMed)32616032 (cikkazonosító)426
Első szerző:	Vincze Anett
Cím:	The risk of fracture and prevalence of osteoporosis is elevated in patients with idiopathic inflammatory myopathies : cross-sectional study from a single Hungarian center / Anett Vincze, Levente Bodoki, Katalin Szabó, Melinda Nagy-Vincze, Orsolya Szalmás, József Varga, Katalin Dankó, János Gaál, Zoltán Griger
Dátum:	2020
ISSN:	1471-2474
Megjegyzések:	Background: The prevalence of osteoporosis and risk of fractures is elevated in rheumatoid arthritis (RA), but we have limited information about the bone mineral density (BMD) and fracture risk in patients with inflammatory myopathies. We intended to ascertain and compare fracture risk, bone mineral density and the prevalence of vertebral fractures in patients with inflammatory myositis and rheumatoid arthritis and to assess the effect of prevalent fractures on the quality of life and functional capacity. Methods: Fifty-two patients with myositis and 43 patients with rheumatoid arthritis were included in the study. Fracture Risk was determined using FRAX? Calculation Tool developed by the University of Sheffield. Dual energy X-ray absorptiometry and bidirectional thoracolumbar radiographs were performed to assess BMD and vertebral fractures. Quality of life was measured with Short Form-36 (SF-36) and physical function assessment was performed using Health Assessment Questionnaire (HAQ). Results: We found a significantly elevated fracture risk in RA as compared to myositis patients if the risk assessment was performed without the inclusion of the BMD results. If BMD results and glucocorticoid dose adjustment were taken into account, the differences in fracture risk were no longer significant. The prevalence of osteoporosis was found to be significantly higher in the myositis group (7% vs. 13.5%, p: 0.045), but the fracture prevalence was similar in the two groups (75% vs. 68%). The fracture rates were independently associated with age in the myositis group, and with lower BMD results in the RA patients. The number of prevalent fractures was significantly correlated to poorer physical function in both groups, and poorer health status in the myositis group, but not in the RA group. Conclusions: Our findings suggest that inflammatory myopathies carry significantly elevated risks for osteoporosis and fractures. These higher risks are comparable to ones detected with RA in studies and strongly affect the physical function and quality of life of patients. Therefore further efforts are required to make the fracture risk assessment reliable and to facilitate the use of early preventive treatments.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Fracture risk Myositis Rheumatoid arthritis Vertebral fractures
Megjelenés:	Bmc Musculoskeletal Disorders. - 21 : 1 (2020), p. 1-8. -
További szerzők:	Bodoki Levente (1986-) (PhD hallgató) Szabó Katalin (1991-) (orvos) Nagy-Vincze Melinda (1985-) (orvos) Szalmás Orsolya Varga József (1955-) (fizikus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Gaál János (1965-) (reumatológus, belgyógyász) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:	Új Nemzeti Kiválóság Program ÚNKP-17-2 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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