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001-es BibID:	BIBFORM087109
Első szerző:	Brücher Ernő (vegyész)
Cím:	Kinetic stabilities of gadolinium(III) chelates used as MRI contrast agents / Ernő Brücher
Dátum:	2002
ISSN:	0340-1022
Megjegyzések:	Equilibrium calculations indicate that the Gd3+ chelates used as contrast agents in MRI may partly dissociate in the body fluids. However, the results of the kinetic studies point to the proton, Cu2+ and Zn2+ assisted dissociation of Gd3+ complexes being slow at pH > 5. The excretion of these contrast agents from the body is relatively fast so that the system is far from the equilibrium and the extent of in vivo dissociation is very low. The rate constants, characterizing the dissociation of Gd3+ chelates, used to compare the kinetic stabilities, are about 103 times lower for the macrocyclic DOTA derivative complexes than for the complexes of the open-chain DTPA derivatives. The rigid structure of ligands is highly important for the inertness of the complexes. The use of functional groups in the ligands, possessing donor atoms of lower basicity (e.g. amide, phosphinate or phosphonate ester), result in significantly lower stability constants, but the kinetic stability of complexes is practially not influenced. Substituents, attached to the diethylenetriamine backbone, increase the kinetic stability of the DTPA derivative complexes.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk gadolinium contrast agents dissociation kinetics kinetic stability stability constants
Megjelenés:	Topics In Current Chemistry. - 221 (2002), p. 104-122. -
Pályázati támogatás:	T 025462 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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