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001-es BibID:	BIBFORM088119
035-os BibID:	(WOS)000577346400013 (Scopus)85091623657 (cikkazonosító)15898
Első szerző:	Gebri Enikő Zsuzsa (fogszakorvos)
Cím:	Female sex as an independent prognostic factor in the development of oral mucositis during autologous peripheral stem cell transplantation / Enikő Gebri, Attila Kiss, Ferenc Tóth, Tibor Hortobágyi
Dátum:	2020
ISSN:	2045-2322
Megjegyzések:	Oral mucositis (OM) is a frequent complication of stem cell transplantation-associated toxicity in haematological malignancies, contributing to mortality. Therapy still remains mainly supportive. We assessed risk factors in retrospective analysis of 192 autologous peripheral stem cell transplantation patients with lymphoma and multiple myeloma (MM), respectively. Futhermore, we examined the hormone levels both in serum and saliva during transplantation in 7 postmenopausal female patients with lymphoma compared to healthy controls using electrochemiluminescence immunoassay (ECLIA). Multivariable analysis revealed neutrophil engraftment (p?<?0.001; p?=?0.021) and female sex (p?=?0.023; p?=?0.038) as independent predictive factors in the combined patient group and in the lymphoma group, and neutrophil engraftment (p?=?0.008) in the MM group. Of the 85 female participants 19 were pre- and 66 postmenopausal. Fifteen of the pre-, and 49 of the postmenopausal women developed ulcerative mucositis (p?=?0.769), more often with lymphoma than MM (p?=?0.009). Serum estrogen decreased significantly both in postmenopausal controls and transplantated patients compared to premenopausals, with no difference in saliva. Serum progesterone level was significantly (p?=?0.026) elevated at day +?7 of transplantation, while salivary progesterone increased at day +?7 and +?14. Our results indicate a predominantly negative effect of female sex hormones on oral immunity with role in the aetiopathogenesis of OM.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 10 : 1 (2020), p. 1-12. -
További szerzők:	Kiss Attila (1942-) (belgyógyász, haematológus) Tóth Ferenc (1980-) (molekuláris biológus) Hortobágyi Tibor (1965-) (patológus)
Pályázati támogatás:	GINOP-2.3.2.15- 2016-0001 GINOP GINOP-2.3.2-15-2016-00043 GINOP OTKA-NKFIH-SNN 132999 Egyéb
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