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001-es BibID:	BIBFORM088246
Első szerző:	Szabó Gábor Tamás (kardiológus)
Cím:	Hypothetical dysfunction of the epithelial sodium channel may justify neurohumoral blockade in coronavirus disease 2019 / Szabó Gábor Tamás, Kiss Attila, Csanádi Zoltán, Czuriga Dániel
Dátum:	2021
ISSN:	2055-5822
Megjegyzések:	Since the outbreak of the COVID-19 pandemic, substantial effort has been made to understand the mechanism behind increased mortality in infected patients with pre-existing cardiovascular (CV) conditions. As the angiotensin-converting enzyme 2 (ACE2) on the host cell membrane serves as a known cellular entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the use of renin-angiotensin-aldosterone system (RAAS) inhibitors seemed to pose an increased risk due to the potential upregulation of ACE2. In fact, initial assumptions concerning this issue were proven wrong when data regarding the beneficial effects of these drugs in SARS-CoV-2-infected cardiac patients surfaced. Here, we raise a novel hypothesis on the role of the epithelial sodium channel (ENaC) in the cascade of RAAS-mediated CV regulation in COVID-19 cases. Our assumption is based on the potentially reduced bioavailability of the endoprotease furin, leading to insufficient ENaC activation and consequently, RAAS upregulation. This unique mechanism may, in part, be responsible for the advantages of RAAS inhibition in the treatment of COVID-19 patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk EPITHELIAL SODIUM CHANNEL CORONAVIRUS DISEASE ACE2 COVID-19
Megjelenés:	ESC Heart Failure. - 8 : 1 (2021), p. 171-174. -
További szerzők:	Kiss Attila Csanádi Zoltán (1960-) (kardiológus) Czuriga Dániel (1982-) (kardiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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