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001-es BibID:	BIBFORM090191
035-os BibID:	(WoS)000606249500001 (Scopus)85099115203
Első szerző:	Jurca Tünde
Cím:	Formulation of Topical Dosage Forms Containing Synthetic and Natural Anti-Inflammatory Agents for the Treatment of Rheumatoid Arthritis / Tunde Jurca, Liza Józsa, Ramona Suciu, Annamaria Pallag, Eleonora Marian, Ildikó Bácskay, Mariana Mureşan, Roxana Liana Stan, Mariana Cevei, Felicia Cioară, Laura Vicas, Pálma Fehér
Dátum:	2021
ISSN:	1420-3049
Megjegyzések:	Topical anti-inflammatory and analgesic effect for the treatment of rheumatoid arthritis is of major interest because of their fewer side effects compared to oral therapy. The purpose of this study was to prepare different types of topical formulations (ointments and gels) containing synthetic and natural anti-inflammatory agents with different excipients (e.g.,: surfactants, gel-forming) for the treatment of rheumatoid arthritis. The combination of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), diclofenac sodium, a topical analgesic agent methyl salicylate, and a lyophilized extract of Calendula officinalis with antioxidant effect were used in our formulations. The aim was to select the appropriate excipients and dosage form for the formulation in order to enhance the diffusion of active substances and to certify the antioxidant, analgesic, and anti-inflammatory effects of these formulations. To characterize the physicochemical properties of the formulations, rheological studies, and texture profile analysis were carried out. Membrane diffusion and permeability studies were performed with Franz-diffusion method. The therapeutic properties of the formulations have been proven by an antioxidant assay and a randomized prospective study that was carried out on 115 patients with rheumatoid arthritis. The results showed that the treatment with the gel containing diclofenac sodium, methyl salicylate, and lyophilized Calendula officinalis as active ingredients, 2-propenoic acid homopolymer (Synthalen K) as gel-forming excipient, distilled water, triethanolamine, and glycerol had a beneficial analgesic and local anti-inflammatory effect.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Molecules. - 26 : 1 (2021), p. 1-26. -
További szerzők:	Józsa Liza (1994-) (gyógyszerész) Suciu, Ramona Nicoleta Pallag Annamária Marian, Eleonora Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Muresan, Mariana Stan, Roxana Liana Cevei, Mariana Cioară, Felicia Vicas, Laura Fehér Pálma (1976-) (gyógyszerész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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