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001-es BibID:	BIBFORM090863
035-os BibID:	(cikkazonosító)975 (scopus)85100049287 (wos)000611313400001
Első szerző:	Máthé Csaba (biológus)
Cím:	The Protein Phosphatase PP2A Plays Multiple Roles in Plant Development by Regulation of Vesicle Traffic?Facts and Questions / Csaba Máthé, Márta M-Hamvas, Csongor Freytag, Tamás Garda
Dátum:	2021
ISSN:	1661-6596 1422-0067
Megjegyzések:	The protein phosphatase PP2A is essential for the control of integrated eukaryotic cell functioning. Several cellular and developmental events, e.g., plant growth regulator (PGR) mediated signaling pathways are regulated by reversible phosphorylation of vesicle traffic proteins. Reviewing present knowledge on the relevant role of PP2A is timely. We discuss three aspects: (1) PP2A regulates microtubule-mediated vesicle delivery during cell plate assembly. PP2A dephosphorylates members of the microtubule associated protein family MAP65, promoting their binding to microtubules. Regulation of phosphatase activity leads to changes in microtubule organization, which affects vesicle traffic towards cell plate and vesicle fusion to build the new cell wall between dividing cells. (2) PP2A-mediated inhibition of target of rapamycin complex (TORC) dependent signaling pathways contributes to autophagy and this has possible connections to the brassinosteroid signaling pathway. (3) Transcytosis of vesicles transporting PIN auxin efflux carriers. PP2A regulates vesicle localization and recycling of PINs related to GNOM (a GTP?GDP exchange factor) mediated pathways. The proper intracellular traffic of PINs is essential for auxin distribution in the plant body, thus in whole plant development. Overall, PP2A has essential roles in membrane interactions of plant cell and it is crucial for plant development and stress responses.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk protein phosphatase PP2A vesicle traffic phragmoplast cell plate autophagy PIN auxin efflux carriers transcytosis
Megjelenés:	International Journal Of Molecular Sciences. - 22 : 2 (2021), p. 1-18. -
További szerzők:	Mikóné Hamvas Márta (1963-) (biológus) Freytag Csongor (1993-) (biológus) Garda Tamás (1990-) (biológus)
Pályázati támogatás:	Egyéb OTKA ÚNKP-20-3-II-DE-412 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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