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001-es BibID:	BIBFORM091295
035-os BibID:	(WOS)000619709200003 (Scopus)85101478501
Első szerző:	Képes Zita (orvos)
Cím:	Age, BMI and diabetes as independent predictors of brain hypoperfusion / Zita Képes, Ferenc Nagy, Ádám Budai, Sándor Barna, Regina Esze, Sándor Somodi, Miklós Káplár, Ildikó Garai, József Varga
Dátum:	2021
ISSN:	1506-9680 1644-4345
Megjegyzések:	Background: Cerebral blood flow abnormalities are supposed to be potential risk factors for developing cognitive dysfunction in general population. Aging, obesity and type 2 diabetes mellitus are associated with perfusion abnormalities leading to cognitive impairment, neurodegeration and future development of dementia. In our study we aimed at identifying independent factors that contribute to the appearance of brain perfusion changes besides those that are already known. Material and methods: Forty-three type 2 diabetic and twenty-six obese patients were enrolled. After the intravenous administration of 740 MBq Tc99m-hexamethylpropylene amine oxime (HMPAO), all subjects underwent brain perfusion SPECT imaging applying AnyScan S Flex dual-head gamma camera (Mediso, Hungary). Using Philips Achieva 3T scanner brain resting state functional MRI was also performed. The SPECT and MRI images were co-registered and transformed to the MNI152 atlas space so that data of the following standard volumes of interest (VOIs) could be obtained: frontal lobe, parietal lobe, temporal lobe, occipital lobe, limbic region, cingulate, insula, basal ganglia, cerebrum, limbic system and brain stem. Using the SPSS 25 statistical software package, general linear regression analysis, Student's t-test, and Mann-Whitney U test were applied for statistical analyses. Results: Multivariate linear analysis identified that BMI and age are significantly (p<0.0001) associated with perfusion, and patient group was slightly above threshold (p=0.0524). We also found that the presence of diabetes was an independent significant predictor of normalized regional brain perfusion only in the insula (p<0.001). Other independent predictors of normalized regional brain perfusion were: age in the insula (p < 0.001) and in the limbic region (p <0.01), and BMI in the brain stem (p < 0.01). Conclusions: Age and BMI proved to be general, and diabetes regional predictor of brain hypoperfusion. BMI appeared to be a novel factor affecting brain perfusion. In one specific region, the insula we detected difference between the obes and the diabetic group. These findings may be significant in the understanding of the development of cognitive impairment in metabolic diseases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk brain perfusion SPECT type 2 diabetes mellitus obesity insula limbic region brain stem
Megjelenés:	Nuclear Medicine Review. - 24 : 1 (2021), p. 11-15. -
További szerzők:	Nagy Ferenc Budai Ádám Barna Sándor (1982-) (kutató orvos) Esze Regina (1987-) (általános orvos) Somodi Sándor (1977-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus) Garai Ildikó (1966-) (radiológus) Varga József (1955-) (fizikus)
Pályázati támogatás:	2.1.1-15-2015-00609 GINOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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