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001-es BibID:	BIBFORM091958
035-os BibID:	(cikkazonosító)107287
Első szerző:	Lima, Carla
Cím:	Natterin an aerolysin-like fish toxin drives IL-1[beta]-dependent neutrophilic inflammation mediated by caspase-1 and caspase-11 activated by the inflammasome sensor NLRP6 / Lima Carla, Falcao Maria Alice Pimentel, Andrade-Barros Aline Ingrid, Seni-Silva Ana Carolina, Grund Lidiane Zito, Balogh Eniko, Conceicao Katia, Queniaux Valerie F., Ryffel Bernhard, Lopes-Ferreira Monica
Dátum:	2021
ISSN:	1567-5769
Megjegyzések:	Natterin is an aerolysin-like pore-forming toxin responsible for the toxic effects of the venom of the medically significant fish Thalassophryne nattereri. Using a combination of pharmacologic and genetic loss-of-function approaches we conduct a systematic investigation of the regulatory mechanisms that control Natterin-induced neutrophilic inflammation in the peritonitis model. Our data confirmed the capacity of Natterin to induce a strong and sustained neutrophilic inflammation leading to systemic inflammatory lung infiltration and revealed overlapping regulatory paths in its control. We found that Natterin induced the extracellular release of mature IL-1? and the sustained production of IL-33 by bronchial epithelial cells. We confirmed the dependence of both ST2/IL-33 and IL-17A/IL-17RA signaling on the local and systemic neutrophils migration, as well as the crucial role of IL-1?, caspase-1 and caspase-11 for neutrophilic inflammation. The inflammation triggered by Natterin was a gasdermin-D-dependent inflammasome process, despite the cells did not die by pyroptosis. Finally, neutrophilic inflammation was mediated by non-canonical NLRP6 and NLRC4 adaptors through ASC interaction, independent of NLRP3. Our data highlight that the inflammatory process dependent on non-canonical inflammasome activation can be a target for pharmacological intervention in accidents by T. nattereri, which does not have adequate specific therapy.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International Immunopharmacology. - 91 (2021), p. 1-12. -
További szerzők:	Falcao, Maria Alice Pimentel Andrade-Barros, Aline Ingrid Seni-Silva, Ana Carolina Grund, Lidiane Zito Balogh Enikő (1987-) (molekuláris biológus) Conceiçao, Katia Queniaux, Valerie F. Ryffel, Bernhard Lopes-Ferreira, Monica
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